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EP 3 700 594 A2

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(88) Date of publication A3: 26.03.2020 (43) Date of publication: 02.09.2020 Bulletin 2020/36 (21) Application number: 18870556.0 (22) Date of filing: 24.10.2018

(51) International Patent Classification (IPC):  A61L 31/06(2006.01) A61L 31/16(2006.01) A61L 31/12(2006.01) (86) International application number: PCT/US2018/057199 (87) International publication number: WO 2019/084073 (02.05.2019 Gazette 2019/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.10.2017 US 201762576403 P (71) Applicants: Davol Inc. Warwick, RI 02886 (US) University of Pittsburgh - of The Commonwealth System of Higher Education Pittsburgh, PA 15260 (US)

(72) Inventors: CRAPO, Peter, Maughan North Kingstown RI 02852 (US) SHAH, Devang, Vijay Franklin MA 02038 (US) BADYLAK, Stephen, F. Pittsburgh PA 15213 (US) HUSSEY, George Cranberry Township PA 16066 (US) PINEDA MOLINA, Catalina Pittsburgh PA 15232 (US) SICARI, Brian Pittsburgh PA 15220 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)