(19)
(11) EP 3 708 680 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
30.08.2023 Bulletin 2023/35

(45) Mention of the grant of the patent:
26.07.2023 Bulletin 2023/30

(21) Application number: 20153196.9

(22) Date of filing: 15.04.2016
(51) International Patent Classification (IPC): 
A61K 48/00(2006.01)
A61P 25/00(2006.01)
 A61K 49/00(2006.01)
(52) Cooperative Patent Classification (CPC):
G01N 33/5023; C12Q 2600/156; C12Q 2600/158; C12Q 1/6883; A61P 25/00

(54)

COMPOSITIONS AND METHODS FOR XI CHROMOSOME REACTIVATION

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR REAKTIVIERUNG DES XI-CHROMOSOMS

COMPOSITIONS ET PROCÉDÉS DE RÉACTIVATION DU CHROMOSOME XI

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 15.04.2015 US 201562148106 P

(43) Date of publication of application:
16.09.2020 Bulletin 2020/38

(62) Application number of the earlier application in accordance with Art. 76 EPC:
16780874.0 / 3283127

(73) Proprietor: University of Massachusetts
Boston, MA 02108 (US)

(72) Inventors:
  • Green, Michael, R.
    Boylston, MA 01505 (US)
  • Bhatnagar, Sanchita
    Shrewsbury, MA 01545 (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)


(56) References cited: : 
WO-A1-2016/164463
 US-A1- 2011 195 966
   
  • S. BHATNAGAR ET AL: "Genetic and pharmacological reactivation of the mammalian inactive X chromosome", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 35, 18 August 2014 (2014-08-18), pages 12591-12598, XP055321126, US ISSN: 0027-8424, DOI: 10.1073/pnas.1413620111 -& S. BHATNAGAR ET AL: "Genetic and pharmacological reactivation of the mammalian inactive X chromosome", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 35, 18 August 2014 (2014-08-18), pages 12591-12598, XP055499258, US ISSN: 0027-8424, DOI: 10.1073/pnas.1413620111
  • TATSUYA OHHATA ET AL: "Reactivation of the inactive X chromosome in development and reprogramming", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES., vol. 70, no. 14, 30 September 2012 (2012-09-30), pages 2443-2461, XP055499260, DE ISSN: 1420-682X, DOI: 10.1007/s00018-012-1174-3
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).