(19)
(11) EP 3 712 280 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.09.2023 Bulletin 2023/37

(45) Mention of the grant of the patent:
09.08.2023 Bulletin 2023/32

(21) Application number: 20169652.3

(22) Date of filing: 22.12.2017
(51) International Patent Classification (IPC): 
C12Q 1/6883(2018.01)
(52) Cooperative Patent Classification (CPC):
C12Q 2600/158; C12Q 2600/178; C12Q 1/6883; A61P 25/00; A61P 25/20; A61P 9/00

(54)

BIOMARKERS OF TRAUMATIC BRAIN INJURY

BIOMARKER FÜR TRAUMATISCHE HIRNVERLETZUNGEN

BIOMARQUEURS DE TRAUMATISME CRÂNIEN


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 30.01.2017 WO PCT/GB2017/050231

(43) Date of publication of application:
23.09.2020 Bulletin 2020/39

(62) Application number of the earlier application in accordance with Art. 76 EPC:
17822770.8 / 3574117

(73) Proprietor: The University of Birmingham
Birmingham B15 2TT (GB)

(72) Inventors:
  • BELLI, Antonio
    East Wellow Hampshire SO51 6BN (GB)
  • DI PIETRO, Valentina
    Birmingham West Midlands B29 6QJ (GB)

(74) Representative: Haseltine Lake Kempner LLP 
Cheapside House 138 Cheapside
London EC2V 6BJ
London EC2V 6BJ (GB)


(56) References cited: : 
WO-A1-2015/134551
WO-A1-2015/196191
   
  • NAGARAJA BALAKATHIRESAN ET AL: "MicroRNA Let-7i Is a Promising Serum Biomarker for Blast-Induced Traumatic Brain Injury", JOURNAL OF NEUROTRAUMA., vol. 29, no. 7, 1 May 2012 (2012-05-01), pages 1379-1387, XP055356447, US ISSN: 0897-7151, DOI: 10.1089/neu.2011.2146
  • LEI P ET AL: "Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1284, 11 August 2009 (2009-08-11), pages 191-201, XP026391753, ISSN: 0006-8993 [retrieved on 2009-06-06]
  • VALENTINA DI PIETRO ET AL: "MicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury", JOURNAL OF NEUROTRAUMA., 9 March 2017 (2017-03-09), XP055357212, US ISSN: 0897-7151, DOI: 10.1089/neu.2016.4857
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).