(19)

(11)

EP 3 720 429 A1

(12)

(43) Date of publication: 14.10.2020 Bulletin 2020/42 (21) Application number: 17934303.3 (22) Date of filing: 28.12.2017

(51) International Patent Classification (IPC):  A61K 31/192(2006.01) A61K 9/14(2006.01) A61K 31/352(2006.01) (86) International application number: PCT/US2017/064526 (87) International publication number: WO 2019/112552 (13.06.2019 Gazette 2019/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD TN (30) Priority: 04.12.2017 US 201715830980 (71) Applicant: The General Hospital Corporation Boston, MA 02114 (US)	(72) Inventor: ELMALEH, David R. Newton, Massachusetts 02459 (US) (74) Representative: Wynne-Jones IP Limited  2nd Floor, 5210 Valiant Court Gloucester Business Park Gloucester Gloucestershire GL3 4FE Gloucestershire GL3 4FE (GB)