(19)

(11)

EP 3 720 474 A2

(12)

(88) Date of publication A3: 26.09.2019 (43) Date of publication: 14.10.2020 Bulletin 2020/42 (21) Application number: 18885984.7 (22) Date of filing: 06.12.2018

(51) International Patent Classification (IPC):  A61K 38/47(2006.01) C12N 9/24(2006.01) A61P 13/12(2006.01) (86) International application number: PCT/US2018/064333 (87) International publication number: WO 2019/113373 (13.06.2019 Gazette 2019/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 06.12.2017 US 201762595567 P 04.05.2018 US 201862666868 P 29.06.2018 US 201862692195 P 03.12.2018 US 201816208552 (71) Applicant: Klotho Therapeutics, Inc. Las Vegas, Nevada 89109 (US)

(72) Inventors: TARSIO, Joseph F. Manilus New York 13104 (US) RATURI, Dinesh Eastvale California 92880 (US) RAMAGE, William Ian Del Mar California 92014 (US) PLANTE, James R. Las Vegas Nevada 89158 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)