(19)

(11)

EP 3 720 480 A2

(12)

(88) Date of publication A3: 18.07.2019 (43) Date of publication: 14.10.2020 Bulletin 2020/42 (21) Application number: 18847259.1 (22) Date of filing: 07.12.2018

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) C12N 5/0783(2010.01) (86) International application number: PCT/US2018/064630 (87) International publication number: WO 2019/113559 (13.06.2019 Gazette 2019/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.12.2017 US 201762596775 P 14.03.2018 US 201862643165 P 13.04.2018 US 201862657716 P 09.08.2018 US 201862716967 P (71) Applicant: Juno Therapeutics, Inc. Seattle, WA 98109 (US)

(72) Inventors: LARSON, Ryan P. Seattle Washington 98109 (US) YOST, Rachel K. Seattle Washington 98109 (US) HAUSE, Ronald James Jr. Seattle Washington 98109 (US) YEE, Nathan K. Seattle Washington 98109 (US) SUTHERLAND, Claire L. Seattle Washington 98109 (US) RAMSBORG, Christopher Glen Seattle Washington 98109 (US) DEVRIES, Todd Seattle Washington 98109 (US) DAVE, Kedar Himanshu Seattle Washington 98109 (US) (74) Representative: Goodfellow, Hugh Robin  Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA London WC1B 5HA (GB)