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EP 3 720 494 A2

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(88) Date of publication A3: 18.07.2019 (43) Date of publication: 14.10.2020 Bulletin 2020/42 (21) Application number: 18829615.6 (22) Date of filing: 06.12.2018

(51) International Patent Classification (IPC):  A61K 45/06(2006.01) A61P 31/00(2006.01) A61P 37/04(2006.01) A61P 7/06(2006.01) A61P 35/02(2006.01) A61K 35/28(2015.01) A61P 37/06(2006.01) A61P 3/00(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2018/064335 (87) International publication number: WO 2019/113375 (13.06.2019 Gazette 2019/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 06.12.2017 US 201715834017 07.12.2017 US 201762596056 P 13.08.2018 US 201816101676 31.10.2018 US 201862753656 P 30.11.2018 US 201862773954 P (71) Applicant: Magenta Therapeutics, Inc. Cambridge, Massachusetts 02139 (US)

(72) Inventors: MORROW, Dwight West Chester PA 19380 (US) FALAHEE, Patrick C. Somerville MA 02144 (US) BOITANO, Anthony Newton MA 02468 (US) COOKE, Michael P. Brookline MA 02445 (US) GONCALVES, Kevin, A. Boston MA 02116 (US) (74) Representative: EIP  EIP Europe LLP Fairfax House 15 Fulwood Place London WC1V 6HU London WC1V 6HU (GB)