                         SEQUENCE LISTING

<110>  Progenity, Inc.
 
<120>  TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P 
       MODULATOR

<130>  44090-0046WO1

<150>  US 62/687,697
<151>  2018-06-20

<150>  US 62/599,000
<151>  2017-12-14

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  382
<212>  PRT
<213>  Human Sphingosine 1-Phosphate Receptor 1

<400>  1

Met Gly Pro Thr Ser Val Pro Leu Val Lys Ala His Arg Ser Ser Val 
1               5                   10                  15      


Ser Asp Tyr Val Asn Tyr Asp Ile Ile Val Arg His Tyr Asn Tyr Thr 
            20                  25                  30          


Gly Lys Leu Asn Ile Ser Ala Asp Lys Glu Asn Ser Ile Lys Leu Thr 
        35                  40                  45              


Ser Val Val Phe Ile Leu Ile Cys Cys Phe Ile Ile Leu Glu Asn Ile 
    50                  55                  60                  


Phe Val Leu Leu Thr Ile Trp Lys Thr Lys Lys Phe His Arg Pro Met 
65                  70                  75                  80  


Tyr Tyr Phe Ile Gly Asn Leu Ala Leu Ser Asp Leu Leu Ala Gly Val 
                85                  90                  95      


Ala Tyr Thr Ala Asn Leu Leu Leu Ser Gly Ala Thr Thr Tyr Lys Leu 
            100                 105                 110         


Thr Pro Ala Gln Trp Phe Leu Arg Glu Gly Ser Met Phe Val Ala Leu 
        115                 120                 125             


Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile Glu Arg Tyr Ile 
    130                 135                 140                 


Thr Met Leu Lys Met Lys Leu His Asn Gly Ser Asn Asn Phe Arg Leu 
145                 150                 155                 160 


Phe Leu Leu Ile Ser Ala Cys Trp Val Ile Ser Leu Ile Leu Gly Gly 
                165                 170                 175     


Leu Pro Ile Met Gly Trp Asn Cys Ile Ser Ala Leu Ser Ser Cys Ser 
            180                 185                 190         


Thr Val Leu Pro Leu Tyr His Lys His Tyr Ile Leu Phe Cys Thr Thr 
        195                 200                 205             


Val Phe Thr Leu Leu Leu Leu Ser Ile Val Ile Leu Tyr Cys Arg Ile 
    210                 215                 220                 


Tyr Ser Leu Val Arg Thr Arg Ser Arg Arg Leu Thr Phe Arg Lys Asn 
225                 230                 235                 240 


Ile Ser Lys Ala Ser Arg Ser Ser Glu Lys Ser Leu Ala Leu Leu Lys 
                245                 250                 255     


Thr Val Ile Ile Val Leu Ser Val Phe Ile Ala Cys Trp Ala Pro Leu 
            260                 265                 270         


Phe Ile Leu Leu Leu Leu Asp Val Gly Cys Lys Val Lys Thr Cys Asp 
        275                 280                 285             


Ile Leu Phe Arg Ala Glu Tyr Phe Leu Val Leu Ala Val Leu Asn Ser 
    290                 295                 300                 


Gly Thr Asn Pro Ile Ile Tyr Thr Leu Thr Asn Lys Glu Met Arg Arg 
305                 310                 315                 320 


Ala Phe Ile Arg Ile Met Ser Cys Cys Lys Cys Pro Ser Gly Asp Ser 
                325                 330                 335     


Ala Gly Lys Phe Lys Arg Pro Ile Ile Ala Gly Met Glu Phe Ser Arg 
            340                 345                 350         


Ser Lys Ser Asp Asn Ser Ser His Pro Gln Lys Asp Glu Gly Asp Asn 
        355                 360                 365             


Pro Glu Thr Ile Met Ser Ser Gly Asn Val Asn Ser Ser Ser 
    370                 375                 380         


<210>  2
<211>  1149
<212>  DNA
<213>  Human Sphingosine 1-Phosphate Receptor 1

<400>  2
atggggccca ccagcgtccc gctggtcaag gcccaccgca gctcggtctc tgactacgtc       60

aactatgata tcatcgtccg gcattacaac tacacgggaa agctgaatat cagcgcggac      120

aaggagaaca gcattaaact gacctcggtg gtgttcattc tcatctgctg ctttatcatc      180

ctggagaaca tctttgtctt gctgaccatt tggaaaacca agaaattcca ccgacccatg      240

tactatttta ttggcaatct ggccctctca gacctgttgg caggagtagc ctacacagct      300

aacctgctct tgtctggggc caccacctac aagctcactc ccgcccagtg gtttctgcgg      360

gaagggagta tgtttgtggc cctgtcagcc tccgtgttca gtctcctcgc catcgccatt      420

gagcgctata tcacaatgct gaaaatgaaa ctccacaacg ggagcaataa cttccgcctc      480

ttcctgctaa tcagcgcctg ctgggtcatc tccctcatcc tgggtggcct gcctatcatg      540

ggctggaact gcatcagtgc gctgtccagc tgctccaccg tgctgccgct ctaccacaag      600

cactatatcc tcttctgcac cacggtcttc actctgcttc tgctctccat cgtcattctg      660

tactgcagaa tctactcctt ggtcaggact cggagccgcc gcctgacgtt ccgcaagaac      720

atttccaagg ccagccgcag ctctgagaag tcgctggcgc tgctcaagac cgtaattatc      780

gtcctgagcg tcttcatcgc ctgctgggca ccgctcttca tcctgctcct gctggatgtg      840

ggctgcaagg tgaagacctg tgacatcctc ttcagagcgg agtacttcct ggtgttagct      900

gtgctcaact ccggcaccaa ccccatcatt tacactctga ccaacaagga gatgcgtcgg      960

gccttcatcc ggatcatgtc ctgctgcaag tgcccgagcg gagactctgc tggcaaattc     1020

aagcgaccca tcatcgccgg catggaattc agccgcagca aatcggacaa ttcctcccac     1080

ccccagaaag acgaagggga caacccagag accattatgt cttctggaaa cgtcaactct     1140

tcttcctag                                                             1149


<210>  3
<211>  353
<212>  PRT
<213>  Human Sphingosine 1-Phosphate Receptor 2

<400>  3

Met Gly Ser Leu Tyr Ser Glu Tyr Leu Asn Pro Asn Lys Val Gln Glu 
1               5                   10                  15      


His Tyr Asn Tyr Thr Lys Glu Thr Leu Glu Thr Gln Glu Thr Thr Ser 
            20                  25                  30          


Arg Gln Val Ala Ser Ala Phe Ile Val Ile Leu Cys Cys Ala Ile Val 
        35                  40                  45              


Val Glu Asn Leu Leu Val Leu Ile Ala Val Ala Arg Asn Ser Lys Phe 
    50                  55                  60                  


His Ser Ala Met Tyr Leu Phe Leu Gly Asn Leu Ala Ala Ser Asp Leu 
65                  70                  75                  80  


Leu Ala Gly Val Ala Phe Val Ala Asn Thr Leu Leu Ser Gly Ser Val 
                85                  90                  95      


Thr Leu Arg Leu Thr Pro Val Gln Trp Phe Ala Arg Glu Gly Ser Ala 
            100                 105                 110         


Phe Ile Thr Leu Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile 
        115                 120                 125             


Glu Arg His Val Ala Ile Ala Lys Val Lys Leu Tyr Gly Ser Asp Lys 
    130                 135                 140                 


Ser Cys Arg Met Leu Leu Leu Ile Gly Ala Ser Trp Leu Ile Ser Leu 
145                 150                 155                 160 


Val Leu Gly Gly Leu Pro Ile Leu Gly Trp Asn Cys Leu Gly His Leu 
                165                 170                 175     


Glu Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys His Tyr Val Leu 
            180                 185                 190         


Cys Val Val Thr Ile Phe Ser Ile Ile Leu Leu Ala Ile Val Ala Leu 
        195                 200                 205             


Tyr Val Arg Ile Tyr Cys Val Val Arg Ser Ser His Ala Asp Met Ala 
    210                 215                 220                 


Ala Pro Gln Thr Leu Ala Leu Leu Lys Thr Val Thr Ile Val Leu Gly 
225                 230                 235                 240 


Val Phe Ile Val Cys Trp Leu Pro Ala Phe Ser Ile Leu Leu Leu Asp 
                245                 250                 255     


Tyr Ala Cys Pro Val His Ser Cys Pro Ile Leu Tyr Lys Ala His Tyr 
            260                 265                 270         


Phe Phe Ala Val Ser Thr Leu Asn Ser Leu Leu Asn Pro Val Ile Tyr 
        275                 280                 285             


Thr Trp Arg Ser Arg Asp Leu Arg Arg Glu Val Leu Arg Pro Leu Gln 
    290                 295                 300                 


Cys Trp Arg Pro Gly Val Gly Val Gln Gly Arg Arg Arg Gly Gly Thr 
305                 310                 315                 320 


Pro Gly His His Leu Leu Pro Leu Arg Ser Ser Ser Ser Leu Glu Arg 
                325                 330                 335     


Gly Met His Met Pro Thr Ser Pro Thr Phe Leu Glu Gly Asn Thr Val 
            340                 345                 350         


Val 
    


<210>  4
<211>  1062
<212>  DNA
<213>  Human Sphingosine 1-Phosphate Receptor 2

<400>  4
atgggcagct tgtactcgga gtacctgaac cccaacaagg tccaggaaca ctataattat       60

accaaggaga cgctggaaac gcaggagacg acctcccgcc aggtggcctc ggccttcatc      120

gtcatcctct gttgcgccat tgtggtggaa aaccttctgg tgctcattgc ggtggcccga      180

aacagcaagt tccactcggc aatgtacctg tttctgggca acctggccgc ctccgatcta      240

ctggcaggcg tggccttcgt agccaatacc ttgctctctg gctctgtcac gctgaggctg      300

acgcctgtgc agtggtttgc ccgggagggc tctgccttca tcacgctctc ggcctctgtc      360

ttcagcctcc tggccatcgc cattgagcgc cacgtggcca ttgccaaggt caagctgtat      420

ggcagcgaca agagctgccg catgcttctg ctcatcgggg cctcgtggct catctcgctg      480

gtcctcggtg gcctgcccat ccttggctgg aactgcctgg gccacctcga ggcctgctcc      540

actgtcctgc ctctctacgc caagcattat gtgctgtgcg tggtgaccat cttctccatc      600

atcctgttgg ccatcgtggc cctgtacgtg cgcatctact gcgtggtccg ctcaagccac      660

gctgacatgg ccgccccgca gacgctagcc ctgctcaaga cggtcaccat cgtgctaggc      720

gtctttatcg tctgctggct gcccgccttc agcatcctcc ttctggacta tgcctgtccc      780

gtccactcct gcccgatcct ctacaaagcc cactactttt tcgccgtctc caccctgaat      840

tccctgctca accccgtcat ctacacgtgg cgcagccggg acctgcggcg ggaggtgctt      900

cggccgctgc agtgctggag gccgggggtg ggggtgcaag gacggaggcg gggcgggacc      960

ccgggccacc acctcctgcc actccgcagc tccagctccc tggagagggg catgcacatg     1020

cccacgtcac ccacgtttct ggagggcaac acggtggtct ga                        1062


<210>  5
<211>  378
<212>  PRT
<213>  Human Sphingosine 1-Phosphate Receptor 3

<400>  5

Met Ala Thr Ala Leu Pro Pro Arg Leu Gln Pro Val Arg Gly Asn Glu 
1               5                   10                  15      


Thr Leu Arg Glu His Tyr Gln Tyr Val Gly Lys Leu Ala Gly Arg Leu 
            20                  25                  30          


Lys Glu Ala Ser Glu Gly Ser Thr Leu Thr Thr Val Leu Phe Leu Val 
        35                  40                  45              


Ile Cys Ser Phe Ile Val Leu Glu Asn Leu Met Val Leu Ile Ala Ile 
    50                  55                  60                  


Trp Lys Asn Asn Lys Phe His Asn Arg Met Tyr Phe Phe Ile Gly Asn 
65                  70                  75                  80  


Leu Ala Leu Cys Asp Leu Leu Ala Gly Ile Ala Tyr Lys Val Asn Ile 
                85                  90                  95      


Leu Met Ser Gly Lys Lys Thr Phe Ser Leu Ser Pro Thr Val Trp Phe 
            100                 105                 110         


Leu Arg Glu Gly Ser Met Phe Val Ala Leu Gly Ala Ser Thr Cys Ser 
        115                 120                 125             


Leu Leu Ala Ile Ala Ile Glu Arg His Leu Thr Met Ile Lys Met Arg 
    130                 135                 140                 


Pro Tyr Asp Ala Asn Lys Arg His Arg Val Phe Leu Leu Ile Gly Met 
145                 150                 155                 160 


Cys Trp Leu Ile Ala Phe Thr Leu Gly Ala Leu Pro Ile Leu Gly Trp 
                165                 170                 175     


Asn Cys Leu His Asn Leu Pro Asp Cys Ser Thr Ile Leu Pro Leu Tyr 
            180                 185                 190         


Ser Lys Lys Tyr Ile Ala Phe Cys Ile Ser Ile Phe Thr Ala Ile Leu 
        195                 200                 205             


Val Thr Ile Val Ile Leu Tyr Ala Arg Ile Tyr Phe Leu Val Lys Ser 
    210                 215                 220                 


Ser Ser Arg Lys Val Ala Asn His Asn Asn Ser Glu Arg Ser Met Ala 
225                 230                 235                 240 


Leu Leu Arg Thr Val Val Ile Val Val Ser Val Phe Ile Ala Cys Trp 
                245                 250                 255     


Ser Pro Leu Phe Ile Leu Phe Leu Ile Asp Val Ala Cys Arg Val Gln 
            260                 265                 270         


Ala Cys Pro Ile Leu Phe Lys Ala Gln Trp Phe Ile Val Leu Ala Val 
        275                 280                 285             


Leu Asn Ser Ala Met Asn Pro Val Ile Tyr Thr Leu Ala Ser Lys Glu 
    290                 295                 300                 


Met Arg Arg Ala Phe Phe Arg Leu Val Cys Asn Cys Leu Val Arg Gly 
305                 310                 315                 320 


Arg Gly Ala Arg Ala Ser Pro Ile Gln Pro Ala Leu Asp Pro Ser Arg 
                325                 330                 335     


Ser Lys Ser Ser Ser Ser Asn Asn Ser Ser His Ser Pro Lys Val Lys 
            340                 345                 350         


Glu Asp Leu Pro His Thr Ala Pro Ser Ser Cys Ile Met Asp Lys Asn 
        355                 360                 365             


Ala Ala Leu Gln Asn Gly Ile Phe Cys Asn 
    370                 375             


<210>  6
<211>  1137
<212>  DNA
<213>  Human Sphingosine 1-Phosphate Receptor 3

<400>  6
atggcaactg ccctcccgcc gcgtctccag ccggtgcggg ggaacgagac cctgcgggag       60

cattaccagt acgtggggaa gttggcgggc aggctgaagg aggcctccga gggcagcacg      120

ctcaccaccg tgctcttctt ggtcatctgc agcttcatcg tcttggagaa cctgatggtt      180

ttgattgcca tctggaaaaa caataaattt cacaaccgca tgtacttttt cattggcaac      240

ctggctctct gcgacctgct ggccggcatc gcttacaagg tcaacattct gatgtctggc      300

aagaagacgt tcagcctgtc tcccacggtc tggttcctca gggagggcag tatgttcgtg      360

gcccttgggg cgtccacctg cagcttactg gccatcgcca tcgagcggca cttgacaatg      420

atcaaaatga ggccttacga cgccaacaag aggcaccgcg tcttcctcct gatcgggatg      480

tgctggctca ttgccttcac gctgggcgcc ctgcccattc tgggctggaa ctgcctgcac      540

aatctccctg actgctctac catcctgccc ctctactcca agaagtacat tgccttctgc      600

atcagcatct tcacggccat cctggtgacc atcgtgatcc tctacgcacg catctacttc      660

ctggtgaagt ccagcagccg taaggtggcc aaccacaaca actcggagcg gtccatggca      720

ctgctgcgga ccgtggtgat tgtggtgagc gtgttcatcg cctgctggtc cccactcttc      780

atcctcttcc tcattgatgt ggcctgcagg gtgcaggcgt gccccatcct cttcaaggct      840

cagtggttca tcgtgttggc tgtgctcaac tccgccatga acccggtcat ctacacgctg      900

gccagcaagg agatgcggcg ggccttcttc cgtctggtct gcaactgcct ggtcagggga      960

cggggggccc gcgcctcacc catccagcct gcgctcgacc caagcagaag taaatcaagc     1020

agcagcaaca atagcagcca ctctccgaag gtcaaggaag acctgcccca cacagccccc     1080

tcatcctgca tcatggacaa gaacgcagca cttcagaatg ggatcttctg caactga        1137


<210>  7
<211>  384
<212>  PRT
<213>  Human Sphingosine 1-Phosphate Receptor 4

<400>  7

Met Asn Ala Thr Gly Thr Pro Val Ala Pro Glu Ser Cys Gln Gln Leu 
1               5                   10                  15      


Ala Ala Gly Gly His Ser Arg Leu Ile Val Leu His Tyr Asn His Ser 
            20                  25                  30          


Gly Arg Leu Ala Gly Arg Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala 
        35                  40                  45              


Leu Arg Gly Leu Ser Val Ala Ala Ser Cys Leu Val Val Leu Glu Asn 
    50                  55                  60                  


Leu Leu Val Leu Ala Ala Ile Thr Ser His Met Arg Ser Arg Arg Trp 
65                  70                  75                  80  


Val Tyr Tyr Cys Leu Val Asn Ile Thr Leu Ser Asp Leu Leu Thr Gly 
                85                  90                  95      


Ala Ala Tyr Leu Ala Asn Val Leu Leu Ser Gly Ala Arg Thr Phe Arg 
            100                 105                 110         


Leu Ala Pro Ala Gln Trp Phe Leu Arg Glu Gly Leu Leu Phe Thr Ala 
        115                 120                 125             


Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly Glu Arg Phe 
    130                 135                 140                 


Ala Thr Met Val Arg Pro Val Ala Glu Ser Gly Ala Thr Lys Thr Ser 
145                 150                 155                 160 


Arg Val Tyr Gly Phe Ile Gly Leu Cys Trp Leu Leu Ala Ala Leu Leu 
                165                 170                 175     


Gly Met Leu Pro Leu Leu Gly Trp Asn Cys Leu Cys Ala Phe Asp Arg 
            180                 185                 190         


Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Arg Tyr Ile Leu Phe Cys 
        195                 200                 205             


Leu Val Ile Phe Ala Gly Val Leu Ala Thr Ile Met Gly Leu Tyr Gly 
    210                 215                 220                 


Ala Ile Phe Arg Leu Val Gln Ala Ser Gly Gln Lys Ala Pro Arg Pro 
225                 230                 235                 240 


Ala Ala Arg Arg Lys Ala Arg Arg Leu Leu Lys Thr Val Leu Met Ile 
                245                 250                 255     


Leu Leu Ala Phe Leu Val Cys Trp Gly Pro Leu Phe Gly Leu Leu Leu 
            260                 265                 270         


Ala Asp Val Phe Gly Ser Asn Leu Trp Ala Gln Glu Tyr Leu Arg Gly 
        275                 280                 285             


Met Asp Trp Ile Leu Ala Leu Ala Val Leu Asn Ser Ala Val Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Ser Phe Arg Ser Arg Glu Val Cys Arg Ala Val Leu Ser 
305                 310                 315                 320 


Phe Leu Cys Cys Gly Cys Leu Arg Leu Gly Met Arg Gly Pro Gly Asp 
                325                 330                 335     


Cys Leu Ala Arg Ala Val Glu Ala His Ser Gly Ala Ser Thr Thr Asp 
            340                 345                 350         


Ser Ser Leu Arg Pro Arg Asp Ser Phe Arg Gly Ser Arg Ser Leu Ser 
        355                 360                 365             


Phe Arg Met Arg Glu Pro Leu Ser Ser Ile Ser Ser Val Arg Ser Ile 
    370                 375                 380                 


<210>  8
<211>  1095
<212>  DNA
<213>  Human Sphingosine 1-Phosphate Receptor 4

<400>  8
atgaacgcca cggggacccc ggtggccccc gagtcctgcc aacagctggc ggccggcggg       60

cacagccggc tcattgttct gcactacaac cactcgggcc ggctggccgg gcgcgggggg      120

ccggaggatg gcggcctggg ggccctgcgg gggctgtcgg tggccgccag ctgcctggtg      180

gtgctctatt gcctggtgaa catcacgctg agtgacctgc tcacgggcgc ggcctacctg      240

gccaacgtgc tgctgtcggg ggcccgcacc ttccgtctgg cgcccgccca gtggttccta      300

cgggagggcc tgctcttcac cgccctggcc gcctccacct tcagcctgct cttcactgca      360

ggggagcgct ttgccaccat ggtgcggccg gtggccgaga gcggggccac caagaccagc      420

cgcgtctacg gcttcatcgg cctctgctgg ctgctggccg cgctgctggg gatgctgcct      480

ttgctgggct ggaactgcct gtgcgccttt gaccgctgct ccagccttct gcccctctac      540

tccaagcgct acatcctctt ctgcctggtg atcttcgccg gcgtcctggc caccatcatg      600

ggcctctatg gggccatctt ccgcctggtg caggccagcg ggcagaaggc cccacgccca      660

gcggcccgcc gcaaggcccg ccgcctgctg aagacggtgc tgatgatcct gctggccttc      720

ctggtgtgct ggggcccact cttcgggctg ctgctggccg acgtctttgg ctccaacctc      780

tgggcccagg agtacctgcg gggcatggac tggatcctgg ccctggccgt cctcaactcg      840

gcggtcaacc ccatcatcta ctccttccgc agcagggagg tgtgcagagc cgtgctcagc      900

ttcctctgct gcgggtgtct ccggctgggc atgcgagggc ccggggactg cctggcccgg      960

gccgtcgagg ctcactccgg agcttccacc accgacagct ctctgaggcc aagggacagc     1020

tttcgcggct cccgctcgct cagctttcgg atgcgggagc ccctgtccag catctccagc     1080

gtgcggagca tctga                                                      1095


<210>  9
<211>  398
<212>  PRT
<213>  Human Sphingosine 1-Phosphate Receptor 5

<400>  9

Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val 
1               5                   10                  15      


Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro 
            20                  25                  30          


Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala 
        35                  40                  45              


Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His 
    50                  55                  60                  


Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser 
                85                  90                  95      


Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu 
            100                 105                 110         


Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala 
        115                 120                 125             


Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro 
    130                 135                 140                 


Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly 
145                 150                 155                 160 


Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu 
                165                 170                 175     


Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala 
            180                 185                 190         


Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile 
        195                 200                 205             


Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg 
    210                 215                 220                 


Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala 
225                 230                 235                 240 


Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val 
                245                 250                 255     


Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu 
            260                 265                 270         


Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala 
        275                 280                 285             


Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile 
    290                 295                 300                 


Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu 
305                 310                 315                 320 


Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln 
                325                 330                 335     


Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu 
            340                 345                 350         


Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro 
        355                 360                 365             


Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala 
    370                 375                 380                 


Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp 
385                 390                 395             


<210>  10
<211>  1197
<212>  DNA
<213>  Human Sphingosine 1-Phosphate Receptor 5

<400>  10
atggagtcgg ggctgctgcg gccggcgccg gtgagcgagg tcatcgtcct gcattacaac       60

tacaccggca agctccgcgg tgcgcgctac cagccgggtg ccggcctgcg cgccgacgcc      120

gtggtgtgcc tggcggtgtg cgccttcatc gtgctagaga atctagccgt gttgttggtg      180

ctcggacgcc acccgcgctt ccacgctccc atgttcctgc tcctgggcag cctcacgttg      240

tcggatctgc tggcaggcgc cgcctacgcc gccaacatcc tactgtcggg gccgctcacg      300

ctgaaactgt cccccgcgct ctggttcgca cgggagggag gcgtcttcgt ggcactcact      360

gcgtccgtgc tgagcctcct ggccatcgcg ctggagcgca gcctcaccat ggcgcgcagg      420

gggcccgcgc ccgtctccag tcgggggcgc acgctggcga tggcagccgc ggcctggggc      480

gtgtcgctgc tcctcgggct cctgccagcg ctgggctgga attgcctggg tcgcctggac      540

gcttgctcca ctgtcttgcc gctctacgcc aaggcctacg tgctcttctg cgtgctcgcc      600

ttcgtgggca tcctggccgc tatctgtgca ctctacgcgc gcatctactg ccaggtacgc      660

gccaacgcgc ggcgcctgcc ggcacggccc gggactgcgg ggaccacctc gacccgggcg      720

cgtcgcaagc cgcgctcgct ggccttgctg cgcacgctca gcgtggtgct cctggccttt      780

gtggcatgtt ggggccccct cttcctgctg ctgttgctcg acgtggcgtg cccggcgcgc      840

acctgtcctg tactcctgca ggccgatccc ttcctgggac tggccatggc caactcactt      900

ctgaacccca tcatctacac gctcaccaac cgcgacctgc gccacgcgct cctgcgcctg      960

gtctgctgcg gacgccactc ctgcggcaga gacccgagtg gctcccagca gtcggcgagc     1020

gcggctgagg cttccggggg cctgcgccgc tgcctgcccc cgggccttga tgggagcttc     1080

agcggctcgg agcgctcatc gccccagcgc gacgggctgg acaccagcgg ctccacaggc     1140

agccccggtg cacccacagc cgcccggact ctggtatcag aaccggctgc agactga        1197


