(19)
(11) EP 3 724 335 A1

(12)

(43) Date of publication:
21.10.2020 Bulletin 2020/43

(21) Application number: 18830581.7

(22) Date of filing: 10.12.2018
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
(86) International application number:
PCT/US2018/064693
(87) International publication number:
WO 2019/118325 (20.06.2019 Gazette 2019/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 11.12.2017 US 201715837926

(71) Applicants:
  • Rosalind Franklin University of Medicine and Science
    North Chicago, IL 60064 (US)
  • The McLean Hospital Corporation
    Belmont, MA 02487 (US)

(72) Inventors:
  • HASTINGS, Michelle, L.
    Chicago, IL 60064 (US)
  • ISACSON, Ole
    Belmont, MA 02487 (US)
  • KORECKA-ROET, Joanna, A.
    Belmont, MA 02487 (US)

(74) Representative: Müller-Boré & Partner Patentanwälte PartG mbB 
Friedenheimer Brücke 21
80639 München
80639 München (DE)

   


(54) ANTISENSE COMPOUNDS TARGETING LEUCINE-RICH REPEAT KINASE 2 (LRRK2) FOR THE TREATMENT OF PARKINSONS DISEASE