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(11)

EP 3 727 126 A1

(12)

(43) Date of publication: 28.10.2020 Bulletin 2020/44 (21) Application number: 18890819.8 (22) Date of filing: 21.12.2018

(51) International Patent Classification (IPC):  A61B 1/00(2006.01) A61B 1/07(2006.01) A61B 10/06(2006.01) A61B 1/233(2006.01) A61B 1/018(2006.01) A61B 1/015(2006.01) A61J 15/00(2006.01) (86) International application number: PCT/US2018/067152 (87) International publication number: WO 2019/126676 (27.06.2019 Gazette 2019/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.12.2017 US 201715853521 (71) Applicant: The Regents Of The University Of Colorado Denver, CO 80203 (US)	(72) Inventors: FRIEDLANDER, Joel Englewood, CO 80111 (US) PRAGER, Jeremy Englewood, CO 80111 (US) DEBOER, Emily Denver, CO 80209 (US) DETERDING, Robin Boulder, CO 80303 (US) (74) Representative: Verhees, Godefridus Josephus Maria  Brabants Octrooibureau B.V. De Pinckart 54 5674 CC Nuenen 5674 CC Nuenen (NL)