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EP 3 727 362 A1

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(43) Date of publication: 28.10.2020 Bulletin 2020/44 (21) Application number: 18890811.5 (22) Date of filing: 19.12.2018

(51) International Patent Classification (IPC):  A61K 31/138(2006.01) A61K 31/27(2006.01) A61K 31/167(2006.01) (86) International application number: PCT/US2018/066585 (87) International publication number: WO 2019/126378 (27.06.2019 Gazette 2019/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.12.2017 US 201762607749 P 29.08.2018 US 201862724274 P 16.11.2018 US 201862768583 P (71) Applicants: PureTech LYT, Inc. Boston, Massachusetts 02210 (US) Monash University Clayton, Victoria 3800 (AU)

(72) Inventors: BONNER, Daniel Kenneth Sharon, Massachusetts 02067 (US) KARANAM, Ketki Newton, Massachusetts 02458 (US) HAN, Sifei Bundoora, Victoria 3083 (AU) HU, Luojuan Bundoora, Victoria 3083 (AU) PORTER, Christopher John Hamilton Melbourne, Victoria 3205 (AU) QUACH, Tim Southbank, Victoria 3006 (AU) SHYAM, Rishab R. Arlington, Massachusetts 02476 (US) SIMPSON, Jamie Chestnut Hill, Massachusetts 02467 (US) TREVASKIS, Natalie Newington, Victoria 3350 (AU) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)