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EP 3 727 441 A1

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(43) Date of publication: 28.10.2020 Bulletin 2020/44 (21) Application number: 18830986.8 (22) Date of filing: 18.12.2018

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) A61N 1/00(2006.01) A61K 39/29(2006.01) A61P 31/14(2006.01) (86) International application number: PCT/US2018/066157 (87) International publication number: WO 2019/126120 (27.06.2019 Gazette 2019/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.12.2017 WO PCT/US2017/067269 19.12.2017 US 201762607430 P (71) Applicants: Janssen Sciences Ireland Unlimited Company Ringaskiddy, Co Cork (IE) Ichor Medical Systems, Inc. San Diego, CA 92121 (US)

(72) Inventors: BODEN, Daniel 2340 Beerse (BE) HORTON, Helen 2340 Beerse (BE) NEEFS, Jean-Marc Edmond Fernand Marie 2340 Beerse (BE) ROY, Soumitra 2333 CN Leiden (NL) HANNAMAN, Andrew, W. San Diego, CA 92130 (US) BERNARD, Robert, M. Las Vegas, NV 89109-5275 (US) MORSE, Stephen, A. Woodinville, WA 98072 (US) RUCK, Oliver Lewisville, TX 75067 (US) HARTMAN, Adam Denton, TX 76208 (US) COX, Thomas, David Plano, TX 75023 (US) DE POOTER, Dorien 2340 Beerse (BE) (74) Representative: Høiberg P/S  Adelgade 12 1304 Copenhagen K 1304 Copenhagen K (DK)