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(11)

EP 3 728 562 A1

(12)

(43) Date of publication: 28.10.2020 Bulletin 2020/44 (21) Application number: 18892814.7 (22) Date of filing: 19.12.2018

(51) International Patent Classification (IPC):  C12N 5/071(2010.01) A61K 35/12(2015.01) A61L 27/24(2006.01) G01N 33/50(2006.01) C12N 5/077(2010.01) A61K 35/34(2015.01) A61L 27/38(2006.01) (86) International application number: PCT/US2018/066487 (87) International publication number: WO 2019/126315 (27.06.2019 Gazette 2019/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.12.2017 US 201762607511 P (71) Applicant: The Regents of The University of Michigan Ann Arbor, Michigan 48109-2590 (US)	(72) Inventors: HERRON, Todd Ann Arbor, Michigan 48109-2590 (US) FU, Jianping Ann Arbor, Michigan 48109-2590 (US) (74) Representative: Glawe, Delfs, Moll  Partnerschaft mbB von Patent- und Rechtsanwälten Postfach 13 03 91 20103 Hamburg 20103 Hamburg (DE)