(19)

(11)

EP 3 731 729 A2

(12)

(88) Date of publication A3: 08.08.2019 (43) Date of publication: 04.11.2020 Bulletin 2020/45 (21) Application number: 18894997.8 (22) Date of filing: 21.12.2018

(51) International Patent Classification (IPC):  A61B 1/227(2006.01) A61B 1/00(2006.01) (86) International application number: PCT/US2018/067159 (87) International publication number: WO 2019/133496 (04.07.2019 Gazette 2019/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.12.2017 US 201715856865 (71) Applicant: Wisconsin Alumni Research Foundation Madison, WI 53726 (US)	(72) Inventors: REBELLA, Greg Hartland, WI 53029 (US) BERBEE, James Madison, WI 53705 (US) HAMEDANI, Azita Verona, WI 53593 (US) LOPER, Cameron Falls Church, VA 22046 (US) (74) Representative: J A Kemp LLP  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)