(19)

(11)

EP 3 732 191 A2

(12)

(88) Date of publication A3: 08.08.2019 (43) Date of publication: 04.11.2020 Bulletin 2020/45 (21) Application number: 18896769.9 (22) Date of filing: 31.12.2018

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) C12N 15/09(2006.01) C07K 14/725(2006.01) (86) International application number: PCT/US2018/068134 (87) International publication number: WO 2019/133969 (04.07.2019 Gazette 2019/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.12.2017 US 201762612031 P (71) Applicant: Memorial Sloan-Kettering Cancer Center New York, NY 10065 (US)	(72) Inventors: SADELAIN, Michel New York, NY 10024 (US) FEUCHT, Judith 72813 St. Johann, Upfingen (DE) HAMIEH, Mohamad New York, NY 10044 (US) SUN, Jie New York, NY 10044 (US) MANSILLA-SOTO, Jorge A. Forest Hills, NY 11375 (US) (74) Representative: Zacco Denmark A/S  Arne Jacobsens Allé 15 2300 Copenhagen S 2300 Copenhagen S (DK)