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EP 3 735 460 A1

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(43) Date of publication: 11.11.2020 Bulletin 2020/46 (21) Application number: 18856963.6 (22) Date of filing: 17.09.2018

(51) International Patent Classification (IPC):  C12N 15/10(2006.01) C12N 5/10(2006.01) C07K 14/725(2006.01) C07K 14/715(2006.01) C12N 15/867(2006.01) C12N 5/0783(2010.01) C07K 14/705(2006.01) A61K 48/00(2006.01) (86) International application number: PCT/US2018/051392 (87) International publication number: WO 2019/055946 (21.03.2019 Gazette 2019/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 18.09.2017 US 201762560176 P 27.09.2017 US 201762564253 P 28.09.2017 US 201762564991 P 03.03.2018 WO PCT/US2018/020818 06.09.2018 US 201862728056 P (71) Applicant: EXUMA BIOTECH CORP. West Palm Beach, FL 33401 (US)

(72) Inventors: FROST, Gregory Ian West Palm Beach Florida 33401 (US) ONUFFER, James Joseph West Palm Beach Florida 33401 (US) HAERIZADEH, Farzad West Palm Beach Florida 33401 (US) (74) Representative: Turner, Craig Robert et al A.A. Thornton & Co. 15 Old Bailey London EC4M 7EF London EC4M 7EF (GB)