(19)
(11) EP 3 735 461 A1

(12)

(43) Date of publication:
11.11.2020 Bulletin 2020/46

(21) Application number: 18803643.8

(22) Date of filing: 13.11.2018
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
(86) International application number:
PCT/EP2018/081105
(87) International publication number:
WO 2019/092282 (16.05.2019 Gazette 2019/20)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 13.11.2017 EP 17201447
21.06.2018 EP 18179176
28.09.2018 GB 201815921

(71) Applicant: Silence Therapeutics GmbH
13125 Berlin (DE)

(72) Inventors:
  • DAMES, Sibylle
    12435 Berlin (DE)
  • SCHAEPER, Ute
    13125 Berlin (DE)
  • SCHUBERT, Steffen
    14199 Berlin (DE)
  • TENBAUM, Stephan
    88400 Biberach an der Riss (DE)
  • BETHGE, Lucas
    14482 Potsdam (DE)
  • FRAUENDORF, Christian
    13127 Berlin (DE)
  • HAUPTMANN, Judith
    13125 Berlin (DE)
  • WEINGÄRTNER, Adrien
    10318 Berlin (DE)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF ALDH2 IN A CELL