(19)

(11)

EP 3 743 413 A1

(12)

(43) Date of publication: 02.12.2020 Bulletin 2020/49 (21) Application number: 19704152.8 (22) Date of filing: 22.01.2019

(51) International Patent Classification (IPC):  C07D 313/08(2006.01) C07D 333/64(2006.01) C07D 409/12(2006.01) C07D 209/12(2006.01) A61P 35/00(2006.01) A61K 31/404(2006.01) C07C 215/48(2006.01) C07D 487/04(2006.01) C07D 209/30(2006.01) (86) International application number: PCT/US2019/014581 (87) International publication number: WO 2019/144132 (25.07.2019 Gazette 2019/30)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.01.2018 US 201862620441 P (71) Applicant: RADIUS PHARMACEUTICALS, INC. Waltham, MA 02451 (US)	(72) Inventor: MILLER, Chris San Mateo, CA 94402 (US) (74) Representative: Potter Clarkson  The Belgrave Centre Talbot Street Nottingham NG1 5GG Nottingham NG1 5GG (GB)