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EP 3 749 321 A1

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(43) Date of publication: 16.12.2020 Bulletin 2020/51 (21) Application number: 19752055.4 (22) Date of filing: 07.02.2019

(51) International Patent Classification (IPC):  A61K 31/519(2006.01) C07K 16/28(2006.01) C07D 475/04(2006.01) (86) International application number: PCT/US2019/017004 (87) International publication number: WO 2019/157148 (15.08.2019 Gazette 2019/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.02.2018 US 201862627733 P 07.02.2018 US 201862627732 P 14.02.2018 US 201862630625 P 14.02.2018 US 201862630751 P 14.02.2018 US 201862630652 P 14.02.2018 US 201862630620 P 14.02.2018 US 201862630824 P 14.02.2018 US 201862630613 P 28.02.2018 US 201862636289 P 25.04.2018 US 201862662372 P 24.07.2018 US 201862702774 P 24.07.2018 US 201862702779 P 17.08.2018 US 201862764951 P 17.08.2018 US 201862764945 P (71) Applicant: L.E.A.F Holdings Group LLC Gulph Mills, PA 19428 (US)

(72) Inventors: NIYIKIZA, Clet Gulph Mills, PA 19428 (US) MOYO, Victor, Mandla Ringoes, NJ 08551 (US) (74) Representative: FRKelly  27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE)