(19)
(11) EP 3 749 635 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
17.08.2022 Bulletin 2022/33

(45) Mention of the grant of the patent:
13.07.2022 Bulletin 2022/28

(21) Application number: 19703019.0

(22) Date of filing: 23.01.2019
(51) International Patent Classification (IPC): 
C07C 67/39(2006.01)
C07C 51/16(2006.01)
C07C 59/105(2006.01)
 C07C 69/675(2006.01)
C07C 69/732(2006.01)
C07C 59/48(2006.01)
(52) Cooperative Patent Classification (CPC):
C07C 67/39; C07C 51/16; B01J 29/7057
 
C-Sets:
  1. C07C 67/39, C07C 69/675;
  2. C07C 67/39, C07C 69/732;
  3. C07C 51/16, C07C 59/105;
  4. C07C 51/16, C07C 59/48;
(86) International application number:
PCT/EP2019/051632
(87) International publication number:
WO 2019/154624 (15.08.2019 Gazette 2019/33)

(54)

PROCESS OF PRODUCING ALPHA-HYDROXY COMPOUNDS AND USES THEREOF

VERFAHREN ZUR HERSTELLUNG VON ALPHA-HYDROXY-VERBINDUNGEN UND VERWENDUNGEN DAVON

PROCÉDÉ DE PRODUCTION DE COMPOSÉS ALPHA-HYDROXY ET LEURS UTILISATIONS

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 09.02.2018 DK PA201800064

(43) Date of publication of application:
16.12.2020 Bulletin 2020/51

(73) Proprietor: Topsoe A/S
2800 Kgs. Lyngby (DK)

(72) Inventors:
  • TAARNING, Esben
    2000 Frederiksberg (DK)
  • TOLBORG, Søren
    3520 Farum (DK)
  • MARTÍNEZ ESPÍN, Juan Salvador
    2100 Copenhagen (DK)

(74) Representative: Topsoe A/S 
Haldor Topsøes Allé 1
2800 Kgs. Lyngby
2800 Kgs. Lyngby (DK)


(56) References cited: : 
EP-A1- 0 245 231
US-A1- 2017 015 614
 WO-A1-2016/174231
US-A1- 2017 369 434
   
  • VAN DER HEIJDEN, G ET AL.: "Metal-free one pot alpha-carboxylation of primary alcohols.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, no. 41, 1 July 2016 (2016-07-01), pages 9716-9719,
  • VERARDO, G ET AL.: "Exploring the reaction of iodine with alpha-diazo esters.", JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, vol. 22, no. 1, 1 July 2016 (2016-07-01), - 1 July 2016 (2016-07-01), pages 24-30,
  • NGUYEN S T ET AL: "A concise, total synthesis and antibacterial evaluation of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan -3-one", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 20, no. 19, 1 October 2010 (2010-10-01), pages 5739-5742, XP027273552, ISSN: 0960-894X [retrieved on 2010-09-08]
  • GAO, S ET AL.: SYNLETT, vol. 27, no. 11, 8 July 2016 (2016-07-08), - 8 July 2016 (2016-07-08), pages 1748-1752,
  • POTERALA, M. ET AL.: "synthesis of new chiral ionic liquids from alpha-hydroxycarboxylic acids.", TETRAHEDRON: ASYMMETRY, vol. 22, no. 3, 1 July 2016 (2016-07-01), pages 294-299,
  • BALDRIDGE, R.: "Metabolism of histidine. III. Urinary metabolites.", JOURNAL OF BIOLOGICAL SCIENCE, vol. 233, 9 July 2016 (2016-07-09), pages 125-127,
   
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