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(11)

EP 3 752 144 A1

(12)

(43) Date of publication: 23.12.2020 Bulletin 2020/52 (21) Application number: 19754182.4 (22) Date of filing: 11.02.2019

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/5365(2006.01) C07D 471/12(2006.01) A61K 31/53(2006.01) C07D 471/02(2006.01) C07D 471/16(2006.01) (86) International application number: PCT/US2019/017409 (87) International publication number: WO 2019/160783 (22.08.2019 Gazette 2019/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 15.02.2018 US 201862630974 P (71) Applicant: Merck Sharp & Dohme Corp. Rahway, New Jersey 07065-0907 (US)	(72) Inventors: EMBREY, Mark, W. West Point, Pennsylvania 19486 (US) HARTINGH, Timothy John West Point, Pennsylvania 19486 (US) LABROLI, Marc West Point, Pennsylvania 19486 (US) RAHEEM, Izzat, T. West Point, Pennsylvania 19486 (US) (74) Representative: Jaap, David Robert  MSD Hertford Road Hoddesdon, Herts EN11 9BU Hoddesdon, Herts EN11 9BU (GB)