(19)

(11)

EP 3 752 639 A1

(12)

(43) Date of publication: 23.12.2020 Bulletin 2020/52 (21) Application number: 19754491.9 (22) Date of filing: 13.02.2019

(51) International Patent Classification (IPC):  C12Q 1/6869(2018.01) C12Q 1/6886(2018.01) C12Q 1/6855(2018.01) (86) International application number: PCT/US2019/017908 (87) International publication number: WO 2019/160998 (22.08.2019 Gazette 2019/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.02.2018 US 201862630228 P 26.09.2018 US 201862737097 P (71) Applicant: Twinstrand Biosciences, Inc. Seattle, WA 98121 (US)	(72) Inventors: SALK, Jesse J. Seattle, Washington 98125 (US) VALENTINE, Charles Clinton, III Seattle, Washington 98122 (US) (74) Representative: HGF  1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)