(19)
(11) EP 3 756 682 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
27.04.2022 Bulletin 2022/17

(45) Mention of the grant of the patent:
23.03.2022 Bulletin 2022/12

(21) Application number: 20172471.3

(22) Date of filing: 05.10.2016
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
C12N 15/113(2010.01)
A61P 37/04(2006.01)
A61P 35/00(2006.01)
C12N 5/0783(2010.01)
A61P 35/02(2006.01)
C07K 14/725(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 39/0011; A61K 2039/5156; A61K 2039/5158; C12N 2510/00; A61K 35/17; C12N 5/0636; A61P 35/00; A61P 35/02; A61P 37/04; C07K 14/7051; C07K 2319/03

(54)

GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE

GENETISCH VERÄNDERTE ZELLEN MIT GEN AUS KONSTANTER ALPHA-REGION MODIFIZIERTER MENSCHLICHER T-ZELL-REZEPTOREN

CELLULES GÉNÉTIQUEMENT MODIFIÉES COMPRENANT UN GÈNE MODIFIÉ DE RÉGION CONSTANTE ALPHA DE RÉCEPTEUR DE LYMPHOCYTES T HUMAINS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 05.10.2015 US 201562237394 P
19.02.2016 US 201662297426 P

(43) Date of publication of application:
30.12.2020 Bulletin 2020/53

(60) Divisional application:
22163286.2

(62) Application number of the earlier application in accordance with Art. 76 EPC:
16782371.5 / 3359184

(73) Proprietor: Precision Biosciences, Inc.
Durham, NC 27701 (US)

(72) Inventors:
  • JANTZ, Derek
    Durham, NC 27701 (US)
  • SMITH, James, Jefferson
    Morrisville, NC 27560 (US)
  • NICHOLSON, Michael, G.
    Chapel Hill, NC 27517 (US)
  • MACLEOD, Daniel, T.
    La Jolla, CA 92037 (US)
  • ANTONY, Jeyaraj
    Chapel Hill, NC 27516 (US)
  • BARTSEVICH, Victor
    Durham, NC 27713 (US)

(74) Representative: Grund, Martin et al
Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16
80754 München
80754 München (DE)


(56) References cited: : 
WO-A1-2013/176915
WO-A1-2014/191527
WO-A1-2017/062439
WO-A2-2017/180989
WO-A1-2014/191128
WO-A1-2015/057980
WO-A1-2017/156484
   
  • L. POIROT ET AL: "Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies", CANCER RESEARCH, vol. 75, no. 18, 16 July 2015 (2015-07-16) , pages 3853-3864, XP055221500, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-14-3321
  • MACLEOD DANIEL T ET AL: "Generation of a Novel Allogeneic CAR T Cell Platform Utilizing an Engineered Meganuclease and AAV Donor Template to Achieve Efficient Disruption of T Cell Receptor Expression and Simultaneous Homology-Directed Insertion of a CD19 CAR", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 24, no. Suppl.1, 1 May 2016 (2016-05-01), page S156, XP009192715, ISSN: 1525-0016
  • BAECKSEUNG LEE ET AL: "323. Efficient Generation of CART Cells by Homology Directed Transgene Integration into the TCR-Alpha Locus", MOLECULAR THERAPY, vol. 24, no. s1, 1 May 2016 (2016-05-01), pages S130-s130, XP055338267, GB ISSN: 1525-0016, DOI: 10.1016/S1525-0016(16)33132-X
  • MARC CARTELLIERI ET AL: "Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer", JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol. 21, no. 4, 1 January 2010 (2010-01-01), pages 427-13, XP055206629, ISSN: 1110-7243, DOI: 10.1155/2010/956304
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).