ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................JBDM Ver 2.0.15 (20th of December) - 2999001/03756682CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120220427W172deBibliographieenBibliographyfrBibliographieEP20172471.3201610052020122120210414enenen201562237394 P20151005US201662297426 P20160219US2022042720221720201230202053202203232022122021102020220427202217A61K 39/00 20060101AFI20210929BHEP C12N 5/0783 20100101ALI20210929BHEP C12N 15/113 20100101ALI20210929BHEP A61P 35/02 20060101ALI20210929BHEP A61P 37/04 20060101ALI20210929BHEP C07K 14/725 20060101ALI20210929BHEP A61P 35/00 20060101ALI20210929BHEP A61K 39/0011 20130101 LI20201218RHEP A61K2039/5156 20130101 LA20170120BHEP A61K2039/5158 20130101 LA20170120BHEP C12N2510/00 20130101 LA20170120BHEP A61K 35/17 20130101 LI20180517BHEP C12N 5/0636 20130101 FI20180913BHEP A61P 35/00 20180101 LI20200327BHEP A61P 35/02 20180101 LI20200327BHEP A61P 37/04 20180101 LI20200331BHEP C07K 14/7051 20130101 LA20210428BHEP C07K2319/03 20130101 LA20210428BHEP deGENETISCH VERÄNDERTE ZELLEN MIT GEN AUS KONSTANTER ALPHA-REGION MODIFIZIERTER MENSCHLICHER T-ZELL-REZEPTORENenGENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENEfrCELLULES GÉNÉTIQUEMENT MODIFIÉES COMPRENANT UN GÈNE MODIFIÉ DE RÉGION CONSTANTE ALPHA DE RÉCEPTEUR DE LYMPHOCYTES T HUMAINSWO-A1-2013/176915WO-A1-2014/191128WO-A1-2014/191527WO-A1-2015/057980WO-A1-2017/062439WO-A1-2017/156484WO-A2-2017/180989L. POIROT ET AL: "Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies", CANCER RESEARCH, vol. 75, no. 18, 16 July 2015 (2015-07-16) , pages 3853-3864, XP055221500, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-14-3321MACLEOD DANIEL T ET AL: "Generation of a Novel Allogeneic CAR T Cell Platform Utilizing an Engineered Meganuclease and AAV Donor Template to Achieve Efficient Disruption of T Cell Receptor Expression and Simultaneous Homology-Directed Insertion of a CD19 CAR", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 24, no. Suppl.1, 1 May 2016 (2016-05-01), page S156, XP009192715, ISSN: 1525-0016BAECKSEUNG LEE ET AL: "323. Efficient Generation of CART Cells by Homology Directed Transgene Integration into the TCR-Alpha Locus", MOLECULAR THERAPY, vol. 24, no. s1, 1 May 2016 (2016-05-01), pages S130-s130, XP055338267, GB ISSN: 1525-0016, DOI: 10.1016/S1525-0016(16)33132-XMARC CARTELLIERI ET AL: "Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer", JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol. 21, no. 4, 1 January 2010 (2010-01-01), pages 427-13, XP055206629, ISSN: 1110-7243, DOI: 10.1155/2010/95630416782371.533591842016100522163286.220220321JANTZ, Derek1011 Gloria AvenueDurham, NC 27701USSMITH, James, Jefferson1916 Weaver Forest WayMorrisville, NC 27560USNICHOLSON, Michael, G.419 Overland DriveChapel Hill, NC 27517USMACLEOD, Daniel, T.560 Fern GlenLa Jolla, CA 92037USANTONY, Jeyaraj102 Sonoma WayChapel Hill, NC 27516USBARTSEVICH, Victor1008 Odyssey DriveDurham, NC 27713USPrecision Biosciences, Inc.101260069229-013T1302 East Pettigrew Street Dibrell Building, Suite A-100Durham, NC 27701USGrund, Martinet al101346044Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 1680754 MünchenDEALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTR