(19)
(11) EP 3 758 707 A1

(12)

(43) Date of publication:
06.01.2021 Bulletin 2021/01

(21) Application number: 19708981.6

(22) Date of filing: 26.02.2019
(51) International Patent Classification (IPC): 
A61K 31/522(2006.01)
 A61P 35/00(2006.01)
(86) International application number:
PCT/EP2019/054729
(87) International publication number:
WO 2019/166432 (06.09.2019 Gazette 2019/36)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 28.02.2018 WO PCT/CN2018/077501

(71) Applicant: F. Hoffmann-La Roche AG
4070 Basel (CH)

(72) Inventors:
  • POESCHINGER, Thomas
    82377 Penzberg (DE)
  • RIES, Carola
    82377 Penzberg (DE)
  • SHEN, Hong
    Shanghai 201203 (CN)
  • YUN, Hongying
    Shanghai 201203 (CN)
  • HOVES, Sabine
    82377 Penzberg (DE)
  • HAGE, Carina
    82377 Penzberg (DE)

(74) Representative: Jenni, Wolfgang 
Roche Diagnostics GmbH Patent Department (TR-E) Nonnenwald 2
82377 Penzberg
82377 Penzberg (DE)

   


(54) 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF LIVER CANCER