| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
|
Designated Extension States: |
|
BA ME |
|
Designated Validation States: |
|
KH MA MD TN |
| (30) |
Priority: |
26.02.2018 US 201862635133 P
|
| (43) |
Date of publication of application: |
|
06.01.2021 Bulletin 2021/01 |
| (60) |
Divisional application: |
|
24210822.3 |
| (73) |
Proprietor: Synthorx, Inc. |
|
Bridgewater NJ 08807 (US) |
|
| (72) |
Inventors: |
|
- CAFFARO, Carolina E.
La Jolla, California 92037 (US)
- PTACIN, Jerod
La Jolla, California 92037 (US)
- MILLA, Marcos
La Jolla, California 92037 (US)
|
| (74) |
Representative: Hoffmann Eitle |
|
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München
81925 München (DE) |
| (56) |
References cited: :
EP-A1- 3 064 507
WO-A1-2019/166946
US-A1- 2006 057 680
US-A1- 2010 015 723
US-A1- 2016 367 635
US-A1- 2017 369 871
US-B2- 9 328 159
|
WO-A1-2019/028419
WO-A2-2015/153753
US-A1- 2008 300 163
US-A1- 2010 086 517
US-A1- 2017 035 898
US-B2- 7 858 081
|
|
| |
|
|
- ANONYMOUS: "Designing Optimized Biologics Through Our Expanded Genetic Alphabet Platform",
1 January 2019 (2019-01-01), XP055811994, Retrieved from the Internet <URL:https://www.jefferies.com/CMSFiles/Jefferies.com/files/Synthorx%20v2.pdf>
[retrieved on 20210609]
- CAFFARO CAROLINA E: "P613 Discovery of pharmacologically differentiated interleukin
15 (IL-15) agonists employing a synthetic biology platform", JOURNAL FOR IMMUNOTHERAPY
OF CANCER, vol. 7, no. S1, 1 November 2019 (2019-11-01), XP055812005, Retrieved from
the Internet <URL:https://jitc.biomedcentral.com/track/pdf/10.1186/s40425-019-0764-0.pdf>
DOI: 10.1186/s40425-019-0764-0
- CAROLINA E. CAFFARO: "EX-99.1 Discovery of Pharmacologically Differentiated Interleukin
15 (IL-15) Agonists Employing a Synthetic Biology Platform", 1 October 2019 (2019-10-01),
XP055811406, Retrieved from the Internet <URL:https://www.sec.gov/Archives/edgar/data/1609727/000119312519287762/d805399dex991.htm>
[retrieved on 20210608]
- DEITERS A ET AL: "Site-specific PEGylation of proteins containing unnatural amino
acids", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 14,
no. 23, 6 December 2004 (2004-12-06), pages 5743 - 5745, XP004611112, ISSN: 0960-894X,
DOI: 10.1016/J.BMCL.2004.09.059
- KAI-PING HAN ET AL: "IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression
in recombinant mammalian cells, purification and characterization", CYTOKINE, ACADEMIC
PRESS LTD, PHILADELPHIA, PA, US, vol. 56, no. 3, 28 September 2011 (2011-09-28), pages
804 - 810, XP028115119, ISSN: 1043-4666, [retrieved on 20111003], DOI: 10.1016/J.CYTO.2011.09.028
- GUO YIN ET AL: "Immunobiology of the IL-15/IL-15R[alpha] complex as an antitumor and
antiviral agent", CYTOKINE & GROWTH FACTOR REVIEWS, vol. 38, 2017, pages 10 - 21,
XP085253997, ISSN: 1359-6101, DOI: 10.1016/J.CYTOGFR.2017.08.002
|
|
