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EP 3 761 962 A1

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(43) Date of publication: 13.01.2021 Bulletin 2021/02 (21) Application number: 19764715.9 (22) Date of filing: 05.03.2019

(51) International Patent Classification (IPC):  A61K 9/08(2006.01) A61K 39/395(2006.01) A61K 47/22(2006.01) A61K 38/00(2006.01) A61K 47/10(2017.01) A61K 47/32(2006.01) (86) International application number: PCT/US2019/020751 (87) International publication number: WO 2019/173338 (12.09.2019 Gazette 2019/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.03.2018 US 201862639950 P 01.06.2018 US 201862679647 P (71) Applicant: Reform Biologics, LLC Woburn, MA 01801 (US)

(72) Inventors: SOANE, David, S. Palm Beach, FL 33480 (US) WUTHRICH, Philip Watertown, MA 02472 (US) MAHONEY, Robert, P. Newbury, MA 01922 (US) NAIK, Subhashchandra Watertown, MA 02472 (US) TRAN, Timothy Medford, MA 02155 (US) PORTILLA, Rosa, Carado Middleton, MA 01949 (US) GREENE, Daniel, G. Belmont, MA 02478 (US) (74) Representative: Snaith, James Michael et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)