(19)

(11)

EP 3 762 035 A1

(12)

(43) Date of publication: 13.01.2021 Bulletin 2021/02 (21) Application number: 19763624.4 (22) Date of filing: 09.03.2019

(51) International Patent Classification (IPC):  A61K 45/06(2006.01) C07D 453/02(2006.01) C12Q 1/68(2018.01) (86) International application number: PCT/US2019/021502 (87) International publication number: WO 2019/173806 (12.09.2019 Gazette 2019/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.03.2018 US 201862641218 P (71) Applicant: Texas Tech University System Lubbock TX 79409-2021 (US)	(72) Inventors: REYNOLDS, C., Patrick Lubbock, TX 79416 (US) KONERU, Balakrishna Lubbock, TX 79415 (US) MACHA, Shawn Lubbock, TX 79416 (US) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)