(19)
(11) EP 3 773 523 A1

(12)

(43) Date of publication:
17.02.2021 Bulletin 2021/07

(21) Application number: 19776042.4

(22) Date of filing: 26.03.2019
(51) International Patent Classification (IPC): 
A61K 31/00(2006.01)
A61K 31/395(2006.01)
A61K 31/47(2006.01)
A61P 35/02(2006.01)
 A61K 31/33(2006.01)
A61K 31/435(2006.01)
A61P 35/00(2006.01)
A61P 43/00(2006.01)
(86) International application number:
PCT/US2019/023983
(87) International publication number:
WO 2019/191030 (03.10.2019 Gazette 2019/40)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 26.03.2018 US 201862648320 P
10.04.2018 US 201862655407 P
08.06.2018 US 201862682427 P
08.06.2018 US 201862682411 P
08.06.2018 US 201862682419 P

(71) Applicant: Clear Creek Bio, Inc.
Cambridge MA 02139 (US)

(72) Inventors:
  • KUMAR, Vikram S.
    Boston, MA 02215 (US)
  • HESSON, David P.
    Malvern, PA 19355 (US)

(74) Representative: HGF 
1 City Walk
Leeds LS11 9DX
Leeds LS11 9DX (GB)

   


(54) METHODS OF DETERMINING DOSING OF A THERAPEUTIC AGENT BASED ON MEASURED LEVELS OF A METABOLITE