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EP 3 773 585 A1

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(43) Date of publication: 17.02.2021 Bulletin 2021/07 (21) Application number: 19785828.5 (22) Date of filing: 09.04.2019

(51) International Patent Classification (IPC):  A61K 31/496(2006.01) C07K 2/00(2006.01) C12Q 1/68(2018.01) C07D 401/14(2006.01) C12N 15/113(2010.01) G01N 33/566(2006.01) (86) International application number: PCT/US2019/026466 (87) International publication number: WO 2019/199733 (17.10.2019 Gazette 2019/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 10.04.2018 US 201862655308 P (71) Applicant: The Regents Of The University Of Michigan Ann Arbor, Michigan 48109 (US)

(72) Inventors: CHINNAIYAN, Arul ANN ARBOR, Michigan 48109-2590 (US) MALIK, Rohit ANN ARBOR, Michigan 48109-2590 (US) ZHANG, Yajia ANN ARBOR, Michigan 48109-2590 (US) CIESLIK, Marcin ANN ARBOR, Michigan 48109-2590 (US) PITCHIAYA, Sethuramasundaram ANN ARBOR, Michigan 48109-2590 (US) (74) Representative: Glawe, Delfs, Moll  Partnerschaft mbB von Patent- und Rechtsanwälten Postfach 13 03 91 20103 Hamburg 20103 Hamburg (DE)