(19)

(11)

EP 3 781 178 A1

(12)

(43) Date of publication: 24.02.2021 Bulletin 2021/08 (21) Application number: 19789289.6 (22) Date of filing: 16.04.2019

(51) International Patent Classification (IPC):  A61K 35/17(2015.01) C12N 5/09(2010.01) C12N 5/0783(2010.01) (86) International application number: PCT/US2019/027610 (87) International publication number: WO 2019/204261 (24.10.2019 Gazette 2019/43)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.04.2018 US 201862657932 P (71) Applicant: Memorial Sloan Kettering Cancer Center New York, NY 10065 (US)	(72) Inventors: VARDHANA, Santosha New York, NY 10065 (US) FINLEY, Lydia Whitney Stillman New York, NY 10065 (US) THOMPSON, Craig B. New York, NY 10065 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)