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(11)

EP 3 784 241 A1

(12)

(43) Date of publication: 03.03.2021 Bulletin 2021/09 (21) Application number: 19793407.8 (22) Date of filing: 22.04.2019

(51) International Patent Classification (IPC):  A61K 31/4985(2006.01) C07D 487/16(2006.01) (86) International application number: PCT/US2019/028432 (87) International publication number: WO 2019/209667 (31.10.2019 Gazette 2019/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.04.2018 US 201862663377 P 30.04.2018 US 201862664527 P (71) Applicant: Merck Sharp & Dohme Corp. Rahway, New Jersey 07065-0907 (US)

(72) Inventors: YU, Tao Kenilworth, New Jersey 07033 (US) APGAR, James, M. Kenilworth, New Jersey 07033 (US) WHITEHEAD, Alan Rahway, New Jersey 07065-0907 (US) ZHANG, Yonglian Kenilworth, New Jersey 07033 (US) HU, Zhiyong Kenilworth, New Jersey 07033 (US) SHURTLEFF, Valerie, W. West Point, Pennsylvania 19486 (US) MCCAULEY, John, A. West Point, Pennsylvania 19486 (US) RAHEEM, Izzat, T. West Point, Pennsylvania 19486 (US) (74) Representative: Jaap, David Robert  MSD Hertford Road Hoddesdon, Herts EN11 9BU Hoddesdon, Herts EN11 9BU (GB)