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(11)

EP 3 793 982 A1

(12)

(43) Date of publication: 24.03.2021 Bulletin 2021/12 (21) Application number: 19803487.8 (22) Date of filing: 13.05.2019

(51) International Patent Classification (IPC):  C07D 295/185(2006.01) C07C 49/563(2006.01) C07D 207/06(2006.01) C07D 233/61(2006.01) A61K 31/12(2006.01) A61K 31/40(2006.01) A61K 31/407(2006.01) A61K 31/496(2006.01) A61P 35/00(2006.01) C07D 209/52(2006.01) C07D 409/02(2006.01) C07D 207/08(2006.01) C07D 487/04(2006.01) A61K 31/165(2006.01) A61K 31/403(2006.01) A61K 31/495(2006.01) A61K 31/498(2006.01) (86) International application number: PCT/US2019/032033 (87) International publication number: WO 2019/222105 (21.11.2019 Gazette 2019/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.05.2018 US 201862671254 P (71) Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education Pittsburgh, Pennsylvania 15260 (US)

(72) Inventors: MILLIGAN, John Pittsburgh, Pennsylvania 15260 (US) TAI, Serene Pittsburgh, Pennsylvania 15260 (US) NELSON, Joel B. Pittsburgh, Pennsylvania 15213-2582 (US) JOHNSON, James K. Pittsburgh, Pennsylvania 15260 (US) SKODA, Erin M. Silver Spring, Maryland 20910 (US) WANG, Zhou Pittsburgh, Pennsylvania 15232 (US) TAKUBO, Keita Pittsburgh, Pennsylvania 15260 (US) WIPF, Peter Pittsburgh, Pennsylvania 15260 (US) (74) Representative: HGF  1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)