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EP 3 801 489 A1

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(43) Date of publication: 14.04.2021 Bulletin 2021/15 (21) Application number: 19815044.3 (22) Date of filing: 05.06.2019

(51) International Patent Classification (IPC):  A61K 31/21(2006.01) A61K 31/353(2006.01) C07D 311/04(2006.01) A61K 31/352(2006.01) C07D 311/02(2006.01) C07D 311/74(2006.01) (86) International application number: PCT/US2019/035677 (87) International publication number: WO 2019/236772 (12.12.2019 Gazette 2019/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.06.2018 US 201862680965 P 06.12.2018 US 201862776377 P (71) Applicant: Flagship Pioneering Innovations V, Inc. Cambridge, MA 02142 (US)

(72) Inventors: TAYLOR, Steven, John Winchester, MA 01890 (US) KIM, Mi-Jeong Boston, MA 02114 (US) NUDEL, Kathleen Jamaica Plain, MA 02130 (US) BRIGGS, Timothy, F. Waltham, MA 02453 (US) YASUDA, Koji Boston, MA 02116 (US) BUCKBINDER, Leonard East Greenwich, RI 02818 (US) LANTER, Bernard Somerville, MA 02143 (US) PECK, Spencer, Cory Watertown, MA 02472 (US) SNEDEKER, Cheri Boston, MA 02113 (US) SHE, Angela Cambridge, MA 02140 (US) ALEXANDER, Jessica Waltham, MA 02453 (US) LIANG, Anna Everett, MA 02149 (US) LIU, Jenny Cambridge, MA 02140 (US) GUNASEKERA, Dinara Cambridge, MA 02139 (US) BERRY, David, Arthur Waban, MA 02468 (US) CASEY, John Patrick, Jr. Boston, MA 02114 (US) (74) Representative: Dörner, Eva Charlotte  Maiwald Patentanwalts- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München 80335 München (DE)