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(11)

EP 3 801 612 A1

(12)

(43) Date of publication: 14.04.2021 Bulletin 2021/15 (21) Application number: 19729657.7 (22) Date of filing: 29.05.2019

(51) International Patent Classification (IPC):  A61K 39/39(2006.01) A61K 31/7115(2006.01) A61P 37/04(2006.01) A61K 31/711(2006.01) A61K 31/713(2006.01) A61K 39/00(2006.01) (86) International application number: PCT/EP2019/063989 (87) International publication number: WO 2019/229137 (05.12.2019 Gazette 2019/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.05.2018 EP 18174947 (71) Applicants: The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Dublin 2 (IE) TEAGASC, The Agriculture and Food Development Authority Carlow R93 XE12 (IE)

(72) Inventors: LAVELLE, Edward Dublin 2 (IE) DOYLE, Sarah Dublin 8 (IE) HARTE, Ciaran Dublin 2 (IE) BRENNAN, Kiva Dublin 8 (IE) MEADE, Kieran Trim Co. Meath, C15 PW93 (IE) (74) Representative: Hanna Moore + Curley  Garryard House 25-26 Earlsfort Terrace Dublin 2, D02 PX51 Dublin 2, D02 PX51 (IE)