(19)

(11)

EP 3 807 281 A1

(12)

(43) Date of publication: 21.04.2021 Bulletin 2021/16 (21) Application number: 19735024.2 (22) Date of filing: 13.06.2019

(51) International Patent Classification (IPC):  C07D 487/08(2006.01) A61K 31/407(2006.01) C07D 277/52(2006.01) A61P 25/08(2006.01) (86) International application number: PCT/US2019/037011 (87) International publication number: WO 2019/241533 (19.12.2019 Gazette 2019/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.06.2018 US 201862684436 P (71) Applicant: Xenon Pharmaceuticals Inc. Burnaby, British Columbia V5G 4W8 (CA)

(72) Inventors: FOCKEN, Thilo Burnaby, British Columbia V5A 4B2 (CA) BURFORD, Kristen Nicole Burnaby, British Columbia V5H 4W6 (CA) LOFSTRAND, Verner Alexander Burnaby, British Columbia V5E 3S7 (CA) WILSON, Michael Scott Burnaby, British Columbia V3N 4B6 (CA) ZENOVA, Alla Yurevna Vancouver, British Columbia V6J 2B1 (CA) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)