(19)

(11)

EP 3 807 349 A1

(12)

(43) Date of publication: 21.04.2021 Bulletin 2021/16 (21) Application number: 19819280.9 (22) Date of filing: 13.06.2019

(51) International Patent Classification (IPC):  C08J 9/00(2006.01) C12P 19/04(2006.01) C08J 9/28(2006.01) (86) International application number: PCT/US2019/037122 (87) International publication number: WO 2019/241603 (19.12.2019 Gazette 2019/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 13.06.2018 US 201862684661 P 25.06.2018 US 201816017319 (71) Applicant: The Regents Of The University Of Colorado Denver, CO 80203 (US)

(72) Inventors: SMALYUKH, Ivan, I. Boulder, CO 80305 (US) HESS, Andrew, Johnston Louisville, CO 80027 (US) LIU, Quingkun Boulder, CO 80303 (US) DE LA CRUZ, Joshua, A. Denver, CO 80302 (US) FLEURY, Blaise Boulder, CO 80305 (US) ABRAHM, Eldho Boulder, CO 80302 (US) SENYUK, Bohdan Boulder, CO 80309 (US) CHERPAK, Vladyslav Westminster, CO 80234 (US) (74) Representative: Derry, Paul Stefan et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)