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(11)

EP 3 810 003 A1

(12)

(43) Date of publication: 28.04.2021 Bulletin 2021/17 (21) Application number: 19822441.2 (22) Date of filing: 19.06.2019

(51) International Patent Classification (IPC):  A61B 18/04(2006.01) A61N 1/05(2006.01) A61B 18/14(2006.01) A61N 1/00(2006.01) (86) International application number: PCT/US2019/038065 (87) International publication number: WO 2019/246318 (26.12.2019 Gazette 2019/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.06.2018 US 201862686712 P (71) Applicants: Thermaquil, Inc. Devon, PA 19333 (US) University of Pittsburgh - of The Commonwealth System of Higher Education Pittsburgh, PA 15260 (US)

(72) Inventors: POPIELARSKI, Stephen Devon, Pennsylvania 19333 (US) TAI, Changfeng Pittsburgh, Pennsylvania 15260 (US) CHAPMAN, Grant Indianapolis, Indiana 46204 (US) (74) Representative: Cooley (UK) LLP  Dashwood 69 Old Broad Street London EC2M 1QS London EC2M 1QS (GB)