(19)

(11)

EP 3 817 820 A1

(12)

(43) Date of publication: 12.05.2021 Bulletin 2021/19 (21) Application number: 19745408.5 (22) Date of filing: 02.07.2019

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07D 471/04(2006.01) C07D 491/052(2006.01) C07D 513/04(2006.01) A61K 31/437(2006.01) A61K 31/4162(2006.01) C07D 209/40(2006.01) C07D 487/04(2006.01) C07D 495/04(2006.01) A61K 31/404(2006.01) A61K 31/4985(2006.01) A61K 31/407(2006.01) (86) International application number: PCT/US2019/040317 (87) International publication number: WO 2020/010092 (09.01.2020 Gazette 2020/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.07.2018 US 201862693768 P 14.06.2019 US 201962861825 P (71) Applicant: IFM Due, Inc. Boston, MA 02116 (US)	(72) Inventors: ROUSH, William R. Jupiter, FL 33458 (US) VENKATRAMAN, Shankar Lansdale, PA 19446 (US) GLICK, Gary Ann Arbor, MI 48103 (US) SEIDEL, Hans Martin Concord, MA 01742 (US) (74) Representative: D Young & Co LLP  120 Holborn London EC1N 2DY London EC1N 2DY (GB)