(19)

(11)

EP 3 827 083 A2

(12)

(88) Date of publication A3: 30.04.2020 (43) Date of publication: 02.06.2021 Bulletin 2021/22 (21) Application number: 19798704.3 (22) Date of filing: 26.07.2019

(51) International Patent Classification (IPC):  C12N 15/115(2010.01) A61K 31/7088(2006.01) A61K 35/17(2015.01) A61P 35/00(2006.01) (86) International application number: PCT/IB2019/000890 (87) International publication number: WO 2020/021338 (30.01.2020 Gazette 2020/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.07.2018 US 201862703869 P (71) Applicant: aratinga. bio TNP 94800 Villejuif (FR)	(72) Inventors: MIODEK, Anna 91400 Orsay (FR) MOURLANE, Frederic 06000 Nice (FR) BAUCHE, Cecile 75013 Paris (FR) VAILLANT, Renaud 94250 Gentilly (FR) BISHOP, Philippe Foster City, CA 94404 (US) (74) Representative: Cabinet Beau de Loménie  158, rue de l'Université 75340 Paris Cedex 07 75340 Paris Cedex 07 (FR)