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EP 3 843 742 A1

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(43) Date of publication: 07.07.2021 Bulletin 2021/27 (21) Application number: 19855366.1 (22) Date of filing: 28.08.2019

(51) International Patent Classification (IPC):  A61K 31/517(2006.01) C07H 19/16(2006.01) C07D 473/34(2006.01) (86) International application number: PCT/US2019/048552 (87) International publication number: WO 2020/047082 (05.03.2020 Gazette 2020/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.08.2018 US 201862723623 P (71) Applicants: Jiangsu Hengrui Medicine Co., Ltd. Lianyungang, Jiangsu 222047 (CN) Shanghai Hengrui Pharmaceutical Co., Ltd. Shanghai 200245 (CN)

(72) Inventors: LIU, Jian Manalapan, NJ 07726 (US) WU, Heping Edison, NJ 08820 (US) ZHUANG, Linghang Chalfont, PA 18914 (US) LIU, Suxing Edison, NJ 08820 (US) ZHANG, Rumin Edison, NJ 08820 (US) HE, Feng Shanghai 201315 (CN) TAO, Weikang North Brunswick, NJ 08902 (US) (74) Representative: Regimbeau  20, rue de Chazelles 75847 Paris Cedex 17 75847 Paris Cedex 17 (FR)