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(11)

EP 3 846 780 A2

(12)

(88) Date of publication A3: 23.07.2020 (43) Date of publication: 14.07.2021 Bulletin 2021/28 (21) Application number: 19857764.5 (22) Date of filing: 07.08.2019

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 47/42(2017.01) C12N 9/24(2006.01) A61K 38/46(2006.01) C12N 9/16(2006.01) C12N 9/40(2006.01) (86) International application number: PCT/US2019/045491 (87) International publication number: WO 2020/050947 (12.03.2020 Gazette 2020/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.09.2018 US 201862727465 P 06.02.2019 US 201962802104 P 06.02.2019 US 201962801110 P 07.02.2019 US 201962802558 P 07.02.2019 US 201962802568 P 01.03.2019 US 201962812592 P (71) Applicant: Sangamo Therapeutics, Inc. Brisbane, CA 94005 (US)

(72) Inventors: CAO, Liching Brisbane, California 94005 (US) PAN, Yonghua Brisbane, California 94005 (US) WANG, Shelley Q. Brisbane, California 94005 (US) (74) Representative: Marshall, Cameron John  Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA London WC1B 5HA (GB)