(19)

(11)

EP 3 846 816 A1

(12)

(43) Date of publication: 14.07.2021 Bulletin 2021/28 (21) Application number: 19858466.6 (22) Date of filing: 06.09.2019

(51) International Patent Classification (IPC):  A61K 31/497(2006.01) A61P 25/16(2006.01) A61P 25/28(2006.01) A61K 31/496(2006.01) (86) International application number: PCT/US2019/049927 (87) International publication number: WO 2020/051435 (12.03.2020 Gazette 2020/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.09.2018 US 201816124974 08.10.2018 US 201816154301 (71) Applicant: Wayne State University Detroit, MI 48202 (US)	(72) Inventor: DUTTA, Aloke K. Troy, Michigan 48098 (US) (74) Representative: GPI Brevets  1330, rue Guillibert de la Lauzière EuroParc de Pichaury Bât B2 13856 Aix en Provence Cedex 3 13856 Aix en Provence Cedex 3 (FR)