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EP 3 846 907 A1

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(43) Date of publication: 14.07.2021 Bulletin 2021/28 (21) Application number: 19773614.3 (22) Date of filing: 07.09.2019

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07D 471/04(2006.01) C07K 5/083(2006.01) C07D 401/14(2006.01) C07D 519/00(2006.01) A61K 31/437(2006.01) (86) International application number: PCT/US2019/050114 (87) International publication number: WO 2020/051564 (12.03.2020 Gazette 2020/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.09.2018 US 201862728581 P (71) Applicants: Arvinas Operations, Inc. New Haven, CT 06511 (US) Yale University New Haven, CT 06510 (US)

(72) Inventors: CREW, Andrew P. Chester, Connecticut 06412 (US) HORNBERGER, Keith R. Southbury, Connecticut 06488 (US) WANG, Jing Milford, Connecticut 06460 (US) CREWS, Craig M. New Haven, Connecticut 06511 (US) JAIME-FIGUEROA, Saul Morris Plains, New Jersey 07950 (US) DONG, Hanqing Madison, Connecticut 06443 (US) QIAN, Yimin Plainsboro, New Jersey 08536 (US) ZIMMERMAN, Kurt Durham, Connecticut 06422 (US) (74) Representative: Forresters IP LLP  Skygarden Erika-Mann-Straße 11 80636 München 80636 München (DE)