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EP 3 853 353 A1

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(43) Date of publication: 28.07.2021 Bulletin 2021/30 (21) Application number: 19936806.9 (22) Date of filing: 08.07.2019

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) A61P 35/00(2006.01) A61K 35/17(2015.01) (86) International application number: PCT/US2019/040889 (87) International publication number: WO 2021/006876 (14.01.2021 Gazette 2021/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: Nantkwest, Inc. San Diego, California 92121 (US)

(72) Inventors: DUGGAL, Rohit San Diego, California 92121 (US) SINHA, Ranjeet San Diego, California 92121 (US) LI, Wenzhao San Diego, California 92121 (US) ISAACSON, Jason San Diego, California 92121 (US) SOON-SHIONG, Patrick San Diego, California 92121 (US) (74) Representative: Hutter, Anton et al Venner Shipley LLP 5 Stirling House Stirling Road The Surrey Research Park Guildford GU2 7RF Guildford GU2 7RF (GB)