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(11)

EP 3 866 981 A1

(12)

(43) Date of publication: 25.08.2021 Bulletin 2021/34 (21) Application number: 19875362.6 (22) Date of filing: 21.10.2019

(51) International Patent Classification (IPC):  B03C 1/30(2006.01) G01N 33/48(2006.01) B03C 1/02(2006.01) G01N 33/00(2006.01) (86) International application number: PCT/US2019/057237 (87) International publication number: WO 2020/086471 (30.04.2020 Gazette 2020/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.10.2018 US 201862748470 P (71) Applicants: The University of Kansas Lawrence, KS 66045 (US) Kansas State University Research Foundation Manhattan, KS 66502 (US)

(72) Inventor: HE, Mei Gainesville, Florida 32608 (US) (74) Representative: Hanna Moore + Curley  Garryard House 25-26 Earlsfort Terrace Dublin 2, D02 PX51 Dublin 2, D02 PX51 (IE)