(19)
(11) EP 3 867 372 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
07.05.2025 Bulletin 2025/19

(45) Mention of the grant of the patent:
02.04.2025 Bulletin 2025/14

(21) Application number: 19795751.7

(22) Date of filing: 14.10.2019
(51) International Patent Classification (IPC): 
C12N 15/10(2006.01)
 C12N 15/63(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/102; C12N 2840/44; C12N 15/902
 
C-Sets:
C12N 15/102, C12Q 2521/301;
(86) International application number:
PCT/US2019/056083
(87) International publication number:
WO 2020/081438 (23.04.2020 Gazette 2020/17)

(54)

METHODS FOR TARGETED INSERTION OF DNA IN GENES

VERFAHREN ZUR GEZIELTEN INSERTION VON DNA IN GENEN

PROCÉDÉS D'INSERTION CIBLÉE D'ADN DANS DES GÈNES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 16.10.2018 US 201862746497 P
08.04.2019 US 201962830654 P
20.06.2019 US 201962864432 P

(43) Date of publication of application:
25.08.2021 Bulletin 2021/34

(60) Divisional application:
25164748.3

(73) Proprietor: BlueAllele Corporation
Oakdale MN 55128 (US)

(72) Inventor:
  • BALTES, Nicholas
    Oakdale, MN 55128 (US)

(74) Representative: Fish & Richardson P.C. 
Highlight Business Towers Mies-van-der-Rohe-Straße 8
80807 München
80807 München (DE)


(56) References cited: : 
WO-A1-2015/089351
 WO-A2-2016/109840
   
  • ROBERT FRANÇOIS ED - NARETTO RANGEL DRAUZIO EDUARDO: "Bidirectional terminators: an underestimated aspect of gene regulation", CURRENT GENETICS, NEW YORK, NY, US, vol. 64, no. 2, 10 October 2017 (2017-10-10), pages 389 - 391, XP036454568, ISSN: 0172-8083, [retrieved on 20171010], DOI: 10.1007/S00294-017-0763-Y
  • SHUMING OUYANG ET AL: "CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells", STEM CELLS AND DEVELOPMENT, vol. 27, no. 11, 1 June 2018 (2018-06-01), US, pages 756 - 770, XP055650844, ISSN: 1547-3287, DOI: 10.1089/scd.2017.0209
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).