CROSS-REFERENCE TO RELATED APPLICATION
[Technical Field]
[0002] The present invention relates to a nuclide separating device, and more specifically,
the present invention relates to a nuclide separating device that separates a nuclide
of interest from a sample for performing the evaluation of radioactive properties
of radioactive waste, decommissioned waste, and the like.
[Background Art]
[0003] The evaluation of radioactive properties of radioactive waste (solids, soil, water,
etc.) or decommissioned waste (concrete, metal,
etc.) is a very important factor in the disposal of radioactive waste or the decommissioning
of nuclear power plants. This is because disposal strategies and disposal costs vary
depending on the radioactive concentrations derived through the evaluation of radioactive
properties.
[0004] The evaluation of radioactive properties of radioactive waste and decommissioned
waste is based on the results of gamma nuclide analysis and alpha/beta nuclide analysis.
Among these, in the case of alpha/beta nuclides, chemical separation must be required
due to the radioactive characteristics and the properties of detectors. The chemical
separation technique used in recent years is based on the extraction chromatography
method, and the extraction chromatography method is a method of separating nuclides
of interest and interfering ions after filling a column with resin.
[0005] As such, the chemical separation process is complicated and takes a long time, and
the difference in separation efficiency may be large depending on the skill of the
analyst. In order to solve such a problem, an automatic nuclide separating device
that automatically performs nuclide separation using chemical separation technology
has been introduced.
[0006] However, the automatic nuclide separating device according to the prior art has a
limitation in terms of throughput, because the maximum number of samples that can
be continuously separated is eight. Accordingly, there is a need to develop a nuclide
separating device capable of increasing the efficiency of a process in which a large
number of samples are generated, such as a process for evaluating radioactive characteristics
of decommissioned wastes in which 40 or more samples are generated per day and the
like.
[Disclosure]
[Technical Problem]
[0007] The present invention is to solve the problems of the prior art described above,
and the present invention aims to provide a nuclide separating device capable of continuously
performing nuclide separation for a number of samples.
[Technical Solution]
[0008] According to an aspect of the present invention, provided is a nuclide separating
device including a column arrangement part in which a plurality of columns are arranged;
a first fluid channel through which a reagent or sample to be introduced into each
of the columns arranged in the column arrangement part is transferred; a second fluid
channel through which a purified sample or waste discharged from the column is delivered
to a collection part; a fluid channel forming part for connecting or disconnecting
the first fluid channel and the second fluid channel to or from a random column arranged
in the column arrangement part; a main pump for supplying pressure to introduce the
reagent or the sample into the first fluid channel and to discharge the purified sample
or waste from the column; and a transfer part for transferring the fluid channel forming
part so that the fluid channel forming part can connect or disconnect the first fluid
channel and the second fluid channel to or from another random column arranged in
the column arrangement part.
[0009] In this case, the transfer part may be capable of transferring the fluid channel
forming part back and forth, and left and right.
[0010] In addition, the fluid channel forming part may include a first fluid channel connection
part disposed above the column to connect or disconnect the first fluid channel to
or from the upper portion of the column; a second fluid channel connection part disposed
below the column to connect or disconnect the second fluid channel to or from the
lower portion of the column; and an operational part for lowering or raising the first
fluid channel connection part to connect or disconnect the first fluid channel to
or from the upper portion of the column, and raising or lowering the second fluid
channel connection part to connect or disconnect the second fluid channel to or from
the lower portion of the column.
[0011] In addition, the collection part may include a purified sample collection container
in which the purified sample is collected, and a waste collection container in which
the waste is collected, and the fluid channel forming part may further include a discharge
selection valve for selectively connecting the second fluid channel connection part
to any one of the purified sample collection container and the waste collection container.
[0012] In addition, the nuclide separating device may further include a reagent supply part
for selecting a random reagent among a plurality of reagents and supplying the same
to the first fluid channel; a sample supply part for supplying the sample to the first
fluid channel; and an inlet selection valve disposed in the first fluid channel to
selectively connect the first fluid channel to any one of the reagent supply part
and the sample supply part.
[0013] In addition, the sample supply part may include a needle for penetrating into a sample
container containing the sample; a sample supply fluid channel formed between the
needle and the inlet valve; and a needle transfer part for transferring the needle.
[0014] In addition, the sample supply part may further include a washing solution container
containing a washing solution for washing the sample supply fluid channel, the first
fluid channel, and the second fluid channel, and the needle transfer part may be capable
of transferring the needle to penetrate into the washing solution container.
[0015] In addition, the sample supply part may include a plurality of sample containers
for containing each different sample, and the needle and the needle transfer part
may be controlled in a predetermined manner so that the samples in a plurality of
sample containers and a washing solution in the washing solution container are supplied
to the sample supply fluid channel according to a predetermined order.
[0016] In addition, the collection part may include a purified sample collection container
in which the purified sample is collected, and a waste collection container in which
the waste is collected; and a residual washing solution discharge part for transferring
the residual washing solution in the washing solution container to the waste collection
container.
[0017] In addition, the residual washing solution discharge part may include a washing solution
discharge fluid channel formed between the washing solution container and the waste
collection container; and a residual washing solution discharge pump for supplying
pressure so that the residual washing solution is introduced into the washing solution
discharge fluid channel.
[Advantageous Effects]
[0018] According to an exemplary embodiment of the present invention, extraction of a plurality
of columns can be efficiently performed through a fluid channel forming part for connecting
or disconnecting a random column disposed in the column arrangement part to or from
a transfer part for transferring the fluid channel forming part.
[Description of Drawings]
[0019]
FIG. 1 is a configurational diagram of a nuclide separating device according to an
exemplary embodiment of the present invention.
FIG. 2 is a view showing an implementation example of a column arrangement part according
to an exemplary embodiment of the present invention.
FIG. 3 is a view showing an embodiment of the fluid channel forming part of a nuclide
separating device according to an exemplary embodiment of the present invention.
FIG. 4 is a view briefly showing the arrangement of columns and the transfer of the
fluid channel forming part in a nuclide separating device according to an exemplary
embodiment of the present invention.
FIGS. 5 and 6 are perspective views of a nuclide separating device according to another
exemplary embodiment of the present invention.
FIG. 7 is a perspective view of the fluid channel structure of a separation part of
a nuclide separating device according to another exemplary embodiment of the present
invention.
FIGS. 8 and 9 are views showing the operational process of a nuclide separating device
according to another exemplary embodiment of the present invention.
[Modes of the Invention]
[0020] Hereinafter, exemplary embodiments of the present invention will be described in
detail with reference to the accompanying drawings such that those skilled in the
art to which the present invention pertains may easily practice. The present invention
may be implemented in many different forms and is not limited to the exemplary embodiments
described herein. In order to clearly describe the present invention, parts not relevant
to the description in the drawings are omitted, and like reference numerals are assigned
to the same or similar constitutional elements throughout the specification.
[0021] In the present specification, terms such as "include" or "have" are intended to describe
the presence of features, numbers, steps, operations, components, parts, or a combination
thereof described in the specification, but it is to be understood that it does not
preclude the possibility of the presence or addition of one or more other features,
numbers, steps, operations, components, parts, or a combination thereof.
[0022] FIG. 1 is a configurational diagram of a nuclide separating device according to an
exemplary embodiment of the present invention.
[0023] The nuclide separating device according to an exemplary embodiment of the present
invention is intended to be used in the nuclide analysis required for the evaluation
of radioactive properties of radioactive waste and decommissioned waste, and in particular,
it may be used for chemical separation of alpha/beta nuclides. More specifically,
the nuclide separating device according to an exemplary embodiment of the present
invention allows that continuous chemical separation may be performed after filling
the column with resin for a number of samples according to the extraction chromatography
method of separating nuclides of interest and interference ions.
[0024] Referring to FIG. 1, the nuclide separating device 1a according to an exemplary embodiment
of the present invention includes a column arrangement part 10, a first fluid channel
20, a second fluid channel 30, a reagent supply part 40, a sample supply part 50,
an inlet selection valve 60, a fluid channel forming part 70, a main pump 80, a transfer
part 90, a collection part 100, a washing solution supply part 110, and a residual
washing solution discharge part 120.
[0025] A plurality of columns C1 to Cn are arranged in the column arrangement part 10. The
column arrangement part 10 allows a plurality of columns C1 to Cn to be simultaneously
arranged such that separation of a plurality of samples may be continuously performed.
[0026] The column arrangement part 10 may be formed of a tray having a plurality of column
arranging holes 11 formed in a shape penetrated up and down to expose the upper and
lower portions of the arranged column. Referring to FIG. 2, in an exemplary embodiment
of the present invention, the column arrangement part 10 is formed of a rectangular
tray. Other than the above, depending on the shape of the transfer part 90 to be described
below, the column arrangement part 10 may be formed of a tray of another type such
as an annular shape and the like.
[0027] The columns C1 to Cn are disposed by one in each column arrangement hole 11 of the
column arrangement part 10. The columns C1 to Cn are members into which reagents and
samples are introduced. Resin is filled in the columns C1 to Cn, and reagents and
samples are introduced therein to separate the purified sample including nuclides
of interest and other wastes.
[0028] The first fluid channel 20 is a fluid channel through which reagents or samples to
be introduced into the column disposed in the column arrangement part 10 are transferred.
The first fluid channel 20 is connected to the reagent supply part 40, the sample
supply part 50, and the inflow selection valve 60. Depending on the operation of the
inflow selection valve 60, the first fluid channel 20 may be selectively connected
to any one of the reagent supply unit 40 and the sample supply unit 50.
[0029] The second fluid channel 30 delivers the purified sample or waste discharged from
the column to the collection part 100. The second fluid channel 30 has one end connected
to the fluid channel forming part 70 and the other end connected to the collecting
part 100.
[0030] The second fluid channel 30 includes Fluid Channel 2-1 through which the purified
sample or waste discharged from the column is introduced, Fluid Channel 2-2 32 for
connecting a discharge selection valve 74 of a fluid channel forming part 70 to a
purified sample collection container 101 of the collection part, and Fluid Channel
2-3 for connecting a discharge selection valve 74 of a fluid channel forming part
70 to a waste collection container 102 of a collection part 100.
[0031] The reagent supply part 40 selects a random reagent among a plurality of reagents
and supplies the same to the first fluid channel 20. In an exemplary embodiment of
the present invention, the reagent supply part 40 may supply six reagents R1 to R6,
and the reagent selection valve 41 selects one reagent of the above and supplies the
same to the first fluid channel.
[0032] Assuming that three reagents are used in the nuclide separating device according
to an exemplary embodiment of the present invention, the first reagent R1 may be for
column optimization, the second reagent R2 may be for washing and removing of interfering
nuclides, and the third reagent R3 may be for extracting the nuclide of interest.
[0033] Meanwhile, when there are many interfering nuclides, more reagents may be used for
washing and removing interfering nuclides, and accordingly, more reagents may be used.
Furthermore, the number of reagents that the reagent supply part 40 may supply or
the form of the reagent selection valve 41 may be changed as necessary.
[0034] The sample supply part 50 supplies a sample to the first fluid channel 20. Herein,
the sample is obtained from radioactive waste and decommissioned waste, and it is
a subject for which it is necessary to determine whether nuclides of interest are
included, the amount thereof, and the like.
[0035] The sample supply part 50 may include a plurality of sample containers S1 to Sn containing
samples, a needle 51 for penetrating into the sample container containing the sample,
a sample supply fluid channel 52 formed between the needle 51 and the inflow selection
valve 60, and a needle transfer part 53 for transferring the needle.
[0036] When the sample contained in any one of the sample containers is supplied to the
first fluid channel 20 and the extraction of the nuclide of interest is performed,
the needle transfer part 53 may transfer the needle 51 such that the sample contained
in the other sample container may be supplied to the first fluid channel 20.
[0037] The sample supply part 50 may further include a washing solution container V containing
a washing solution for washing the fluid channel. For accurate analysis, after extracting
a nuclide of interest for one sample and before supplying another sample to the first
fluid channel 20, it is necessary to wash the sample supply fluid channel 52, the
first fluid channel 20, the second fluid channel 30, and the like, and the needle
transfer part 53 may transfer the needle 51 to penetrate into the washing solution
container V.
[0038] Meanwhile, the sample supply part 50 may be automated by a computer program. For
example, the needle 51 and the needle transfer part 53 are controlled by a computer
program to continuously perform the separation of the nuclide of interest for a plurality
of samples to operate such that the sample in a plurality of sample containers S1
to Sn and the washing solution in the washing solution container V are supplied to
the fluid channel in a predetermined order.
[0039] The inflow selection valve 60 selectively connects the first fluid channel 20 to
any one of the reagent supply part 40 and the sample supply part 50. The inflow selection
valve 60 may be connected to one end of the first fluid channel 20 to connect the
first fluid channel 20 to the reagent supply part 40 or the sample supply part 50.
[0040] The fluid channel forming unit 70 connects or disconnects the first fluid channel
20 and the second fluid channel 30 to or from a random column arranged in the column
arrangement part 10. In an exemplary embodiment of the present invention, the fluid
channel forming part 70 includes a first fluid channel connection part 71, a second
fluid channel connection part 72, an operational part 73, and a discharge selection
valve 74.
[0041] The first fluid channel connection part 71 is disposed above the column to connect
or disconnect the first fluid channel 20 to or from the upper portion of the column.
The second fluid channel connection part 73 is disposed below the column to connect
or disconnect the second fluid channel 30 to or from the lower portion of the column.
The operational part 73 lowers or raises the first fluid channel connection part 71
to connect or disconnect the first fluid channel 20 to or from the upper portion of
the column, and raises or lowers the second fluid channel connection part 72 to connect
or disconnect the second fluid channel 30 to or from the lower portion of the column.
[0042] Meanwhile, the discharge selection valve 74 selectively connects the second fluid
channel connection part 72 with any one of the purification sample collection container
101 and the waste collection container 102 of the collection unit 100. More specifically,
the discharge selection valve 74 connects the second fluid channel connection part
72 to the waste collection container 102 in the process of optimizing the column and
separating interfering nuclides, and connects the second fluid channel connection
part 72 to the purified sample collection container 101 in the process of extracting
the nuclide of interest.
[0043] FIG. 3 is a view showing an embodiment of the fluid channel forming part of a nuclide
separating device according to an exemplary embodiment of the present invention.
[0044] Referring to FIG. 3, the fluid channel forming part 70 is formed in a '⊏' shape and
is implemented on a plate 701 in a shape in which a column may be arranged between
the upper end and the lower end of one side. The first fluid channel connection part
71, the second fluid channel connection part 72, and the discharge selection valve
74 are disposed to be connected with the operational part 73.
[0045] The operational part 73 includes a guide rail 731 provided in the vertical direction
on the other side of the plate 701, an upper operational body 732 disposed in a shape
that may be raised and lowered from the top of the guide rail 731, and a lower operational
body 733 disposed in a shape that may be raised and lowered from the bottom of the
guide rail 731. In this case, the upper operational body 732 and the lower operational
body 733 may include a servo motor.
[0046] The first fluid channel connection part 71 is coupled to a portion of the upper operational
body 732 that extends to one side of the plate 701, and the second fluid channel connection
part 72 is coupled to a portion of the lower operational body 733 that extends to
one side of the plate 701. In addition, the discharge selection valve 74 may be coupled
to the lower operational body 733 to be integrally operated with the lower operational
body 733.
[0047] When the upper operational body 732 descends and the lower operational body 733 rises,
the first fluid channel connection part 71 and the second fluid channel connection
part 72 are coupled to the upper and lower portions of the column, respectively, to
connect the column, the first fluid channel 20, and the second fluid channel 30. In
this connected state, the reagent or sample is supplied to the column, and optimization
of the column, removal of interfering nuclides, extraction and washing of the nuclides
of interest, and the like are performed.
[0048] When the upper operational body 732 rises and the lower operational body 733 descends,
the first fluid channel connection part 71 and the second fluid channel connection
part 72 are separated from the upper and lower portions of the column, respectively,
to separate the column, the first fluid channel 20, and the second fluid channel 30.
In this separated state, the fluid channel forming part 70 may be transferred to any
random column disposed in the column arrangement part 10 by the transfer part 90.
[0049] The main pump 80 supplies pressure such that the reagent or sample is introduced
into the first fluid channel 20, and the purified sample or waste is discharged from
the column. The main pump 80 may be disposed on the first fluid channel 20.
[0050] While the inflow selection valve 60 connects the first fluid channel 20 to the reagent
supply part 40, the main pump 80 supplies the reagent to the first fluid channel 20,
and while the inlet selection valve 60 connects the first fluid channel 20 to the
sample supply part 50, the main pump 80 supplies the sample to the first fluid channel
20.
[0051] The transfer part 90 transfers a fluid channel forming part 70 such that the fluid
channel forming part 70 may connect or disconnect the first fluid channel 20 and the
second fluid channel 30 to or from any random column arranged in the column arrangement
part 10.
[0052] In an exemplary embodiment of the present invention, the transfer part 90 may transfer
the fluid channel forming part 70 back and forth, and left and right while the fluid
channel forming part 70 is separated from the first fluid channel 20 and the second
fluid channel 30. When the fluid channel forming part 70 is implemented in the same
manner as in FIG. 3, the transfer unit 90 may transfer the plate 701 of the fluid
channel forming part 70 back and forth, and left and right through a ball screw method,
a method of using a motor and a guide rail, or the like. That is, the transfer part
90 may be formed of a ball screw structure, a motor, a guide rail structure, or the
like
[0053] FIG. 4 is a view briefly showing the arrangement of columns and the transfer of the
fluid channel forming part in a nuclide separating device according to an exemplary
embodiment of the present invention.
[0054] Referring to FIG. 4, extraction of a nuclide of interest for one column C1 is performed
in the transfer unit 90, and when the first fluid channel connection part 71 and the
second fluid channel connection part 72 of the fluid channel forming part 70 are separated
from the column C1, the fluid channel forming part 70 may be transferred along the
X-axis or the Y-axis. Accordingly, the fluid channel forming part 70 may be transferred
to one column C1 and a column C2 arranged adjacent to the X-axis direction or a column
C3 arranged adjacent to the Y-axis direction, and the corresponding column C2 or C3
and the first fluid channel 20 and the second fluid channel 30 may be connected. Accordingly,
continuous extraction for a plurality of columns may be efficiently performed.
[0055] The collection part 100 is a part for collecting a purified sample or waste discharged
through the second fluid channel 30. The collection part 100 includes a purified sample
collection container 101 in which purified samples are collected and a waste collection
container 102 in which wastes are collected.
[0056] In an exemplary embodiment of the present invention, the purified sample collection
container 101 may be arranged to correspond one-to-one with the column disposed in
the column arrangement part 10. That is, the purified sample collection container
101 may be arranged in a tray-shaped purified sample collection part (not illustrated)
having a purified sample collection container insertion hole at a position corresponding
to the column position of the column arrangement part 10. Through this arrangement,
continuous separation of nuclides of interest for multiple samples may be performed
more efficiently.
[0057] The washing solution supply part 110 supplies a washing solution to the washing solution
container V of the sample supply part 50. The washing solution supply part 110 includes
a washing solution tank 111, a washing solution supply fluid channel 112, and a washing
solution supply pump 113.
[0058] In an exemplary embodiment of the present invention, the washing solution container
V may include an inner container V1 and an outer container V2 surrounding the inner
container V1. The inner container V1 is a portion in which the washing solution for
washing the sample supply fluid channel 52, the first fluid channel 20, and the second
fluid channel 30 is stored, and the outer container V2 is a portion in which the washing
solution overflowing in the inner container V1 is stored.
[0059] On the premise that the washing solution container V is configured as above, the
washing solution supply fluid channel 112 is formed as the inner container V1 of the
washing solution container V in the washing solution tank 111. That is, the washing
solution in the washing solution tank 111 is supplied to the inner container V1 according
to the operation of the washing solution supply pump 113.
[0060] The residual washing solution discharge part 120 transfers the residual washing solution
in the washing solution container V to the waste collection container 102. Herein,
the residual washing solution refers to a washing solution overflowing from the inner
container V1 and remaining in the outer container V2.
[0061] After washing is performed once, when washing before extraction of the nuclide of
interest for another sample is performed after the extraction of the nuclide of interest
for one sample is performed, using the residual washing solution remaining during
the previous washing may have a risk of contamination, and it is preferable to use
a washing solution newly supplied from the washing solution tank 111.
[0062] The residual washing solution discharge part 120 transfers the residual washing solution
in the outer container V2 of the washing solution container V to the waste collection
container 102 of the collection unit 100 to block the possibility of contamination
during the next washing.
[0063] The residual washing solution discharge part 120 may include a washing solution discharge
fluid channel 121 formed between the washing solution container V and the waste collection
container 102, and a residual washing solution discharge pump 122 disposed in the
washing solution discharge fluid channel 121 to supply pressure to introduce the residual
washing solution into the washing solution discharge fluid channel 121.
[0064] According to an exemplary embodiment of the present invention, the residual washing
solution is discharged to the waste collection container 102 of the collection part
100 rather than a separate waste collection container. Accordingly, the size of the
device may be reduced, and space efficiency may be secured.
[0065] The operational process of the nuclide separating device according to an exemplary
embodiment of the present invention is described as follows.
[0066] First, when the analysis of the first sample is started, the inflow selection valve
60 is connected to the sample supply part 50, while the first fluid channel 20, the
column, and the second fluid channel 30 are connected by the fluid channel forming
part 70. In this case, the washing solution is supplied through the sample supply
part 50 to wash the first fluid channel 20, the main pump 80, the column, the second
fluid channel 30, and the discharge selection valve 74.
[0067] In the washing process, the washing solution in the washing solution tank 111 is
supplied to the inner container V1 according to the operation of the washing solution
supply pump 113, and the residual washing solution in the outer container V2 is discharged
through the washing solution discharge fluid channel 121 to the waste collection container
102 of the collection part 100, according to the operation of the washing solution
discharge pump 122.
[0068] Meanwhile, at the end of the washing process, the needle 51 of the sample supply
part 50 is transferred to the outside of the washing solution container V such that
air is inflowed into the fluid channel to perform the drying of the fluid channel.
[0069] Next, the inlet selection valve 60 is connected to the reagent supply part 40, and
according to the operation of the main pump 80, a reagent for optimizing the column,
that is, a first reagent is supplied to the column, and waste discharged to the lower
portion of the column is collected into the waste collection container 102 of the
collection part 100.
[0070] Subsequently, the inflow selection valve 60 is connected to the sample supply part
50, and the sample is injected into the column according to the operation of the main
pump 80. In addition, the inlet selection valve 60 is connected to the reagent supply
part 40 again, and according to the operation of the main pump 80, one or more reagents
for the removal of interfering nuclides are supplied to the column, and waste discharged
to the bottom of the column is collected in the waste collection container 102 of
the collection part 100.
[0071] Afterwards, the sample supply part 50 supplies a reagent for separation of the nuclides
of interest, and the purified sample is discharged to the bottom of the column according
to the operation of the main pump 80. In this case, the discharge selection valve
74 forms a fluid channel such that the purified sample is introduced into the purified
sample collection container 101 of the collection part 100.
[0072] Afterwards, the inflow selection valve 60 is connected to the sample supply part
50, and again the washing of the fluid channel using the washing solution proceeds
as described above.
[0073] Finally, after washing, while the fluid channel forming part 70 and the first fluid
channel 20 are separated and the column and the second fluid channel 30 are separated,
the fluid channel forming part 70 is transferred to a different column by the transfer
part 90. After the fluid channel forming part 70 is transferred to another column,
the first fluid channel 20, the other column, and the second fluid channel 30 are
connected by the fluid channel forming unit 70, and it may proceed from the optimization
of columns.
[0074] As described above, the nuclide separating device 1a according to an exemplary embodiment
of the present invention forms or releases a fluid channel by connecting or disconnecting
the upper and lower portions of the column to or from other components while the first
fluid channel connection part 71 and the second fluid channel connection part 72 are
operated. In addition, the transfer part 90 transfers the fluid channel forming part
70 while the fluid channel is released. Accordingly, extraction may be continuously
performed by connecting a random column to the sample and connecting another column
to the sample after extraction is completed.
[0075] Hereinafter, a nuclide separating device 1b according to another exemplary embodiment
of the present invention will be described.
[0076] FIGS. 5 and 6 illustrate perspective views of a nuclide separating device according
to another exemplary embodiment of the present invention. The nuclide separating device
1b according to another exemplary embodiment of the present invention is to be used
in the analysis of nuclides required for the evaluation of radioactive properties
of radioactive waste and decommissioned waste, as in the exemplary embodiment of the
present invention, and in particular, it may be used for the chemical separation of
alpha/beta nuclides.
[0077] Referring to FIGS. 5 and 6, the nuclide separating device 1b according to another
exemplary embodiment of the present invention includes a column holding part 1010
in which a column 1011 is disposed, a collection tube holding part 1020 in which a
collection tube 1021 is disposed, a waste discharge part 1030, a separation part 1040,
a connection part 1050, and a transfer part 1060.
[0078] The column 1011 is a member through which reagents and samples are introduced. The
column 1011 is filled with resin, and reagents and samples are introduced therein
to separate the purified sample including the nuclides of interest and other wastes.
Samples and reagents may be stored in separate sample tanks (not illustrated) and
reagent tanks (not illustrated), respectively, and these may be transferred by a pump
(not illustrated) and introduced into the column 1011.
[0079] A plurality of columns 1011 are disposed in the column holding part 1010. The column
holding part 1010 allows a plurality of columns 1011 to be simultaneously disposed
such that separation of a plurality of samples may be continuously performed. The
column holding part 1010 may be formed such that a plurality of columns 1011 are arranged
in an annular shape. Specifically, the column holding part 1010 may include any one
of a disc-shaped member, an annular member, and a saw-toothed wheel-shaped member,
and may be configured to be fixed by inserting the column 1011 at regular intervals
along the rim thereof. For example, the column holding part 1010 may be configured
such that 20 columns are simultaneously disposed along the edge thereof.
[0080] Meanwhile, the column holding part 1010 may be integrally connected to the collection
tube holding part 1020 through a support part 1070. The column holding part 1010 may
be integrally moved with the collection tube holding part 1020 by being connected
to the collection tube holding part 1020 through the support part 1070.
[0081] The collection tube 1021 is a container in which the purified sample that has passed
through the column 1011, in other words, the purified sample extracted from the column
1011 is collected. The collection tube 1021 is disposed corresponding to the lower
portion of each column 1011 disposed in the column holding part 1010. That is, the
collection tube 1021 is disposed in a one-to-one correspondence to the lower portion
of each column 1011 such that the purified sample extracted from one column 1011 may
be collected from the lower portion thereof.
[0082] The collection tube holding part 1020 is arranged to be spaced apart from the lower
portion of the column holding unit 1010 such that the collection tube 1021 is disposed
corresponding to the lower portion of each column 1011 disposed in the column holding
unit 1010. In another exemplary embodiment of the present invention, the collection
tube holding part 1020 may be configured such that the collection tube 1021 corresponding
to each column 1011 is arranged in an annular shape, similar to the column holding
part 1010. For example, when the column holding part 1010 is configured to simultaneously
arrange 20 columns 1011 in an annular shape, the collection tube holding part 1020
correspondingly has 20 collection tubes 1021 arranged in an annular shape.
[0083] The collection tube holding part 1020 may include any one of a disc-shaped member,
an annular member, and a saw-toothed wheel-shaped member. Looking more specifically,
the collection tube holding part 1020 may include a disc-shaped upper plate 1022 supporting
the upper portion of the collection tube 1021 and a lower plate 1023 in the form of
a saw-toothed wheel supporting the lower end of the collection tube 1021.
[0084] As described above, the collection tube holding part 1020 may be integrally connected
to the column holding part 1010 through the support part 1070. In this case, the support
part 1070 may include a column member for connecting the lower plate 1023 of the collection
tube holding part 1020 to the upper plate 1022, and a column member for connecting
the upper plate 1022 of the collection tube holding part 1020 to the column holding
part 1010, and a plurality of these may be provided at regular intervals for stable
coupling between the column holding part 1010 and the collection tube holding part
1020.
[0085] In another exemplary embodiment of the present invention, the centers of the column
holding part 1010 and the collection tube holding part 1020 are disposed on the same
axis, and the column holding part 1010 and the collection tube holding part 1020 have
a form that may be rotated integrally around the axis.
[0086] The waste discharge part 1030 discharges waste discharged from the column 1011 to
the outside. Separation of the purified sample and waste is performed in the column
1011, and the purified sample is collected in the collection tube 1021, and the waste
is discharged to the outside through the waste discharge part 1030. In another exemplary
embodiment of the present invention, the waste discharge part 1030 may be formed of
a discharge pipe connected to the valve 1042 of the separation part 1040, and the
waste discharge part 1030 may be connected to a waste storage tank (not illustrated).
[0087] The separation part 1040 may be disposed between the column holding part 1010 and
the collection tube holding part 1020, and when connected to the column 1011 and the
collection tube 1021, the purified sample is introduced into the collection tube 1021,
and the waste is separated to be discharged to the waste discharge part 1030. The
separation part 1040 includes a fluid channel structure 1041 and a valve 1042.
[0088] FIG. 7 shows a perspective view of the fluid channel structure of a separation part
of a nuclide separating device according to another exemplary embodiment of the present
invention. Referring to FIG. 7, the fluid channel structure 1041 has a rectangular
block shape as a whole. The fluid channel structure 1041 includes a column connection
part 1411, a first fluid channel 1412, a second fluid channel 1412, and a collection
tube connection part 1414. The column connection part 1411 is formed on the upper
portion of the fluid channel structure 1041 and has a hole shape that may be connected
to the lower portion of the column 1011. The first fluid channel 1412 is a fluid channel
formed toward the valve 1042 from the column connection part 1411 such that the purified
sample or waste introduced through the column connection part 1411 may be transferred
to the valve 1042. In addition, the second fluid channel 1413 is a fluid channel formed
between the valve 1042 and the collection tube connection part 1414 such that the
purified sample passing through the valve 1412 may be introduced into the collection
tube 1021. Meanwhile, the collection tube connection part 1414 is formed at the lower
portion of the fluid channel structure 1041, and has a shape of a tube that may be
connected to the upper portion of the collection tube 1021. The collection tube connection
part 1414 communicates with the second fluid channel 1413.
[0089] In another exemplary embodiment of the present invention, the fluid channel structure
1041 is connected to a frame F and is installed on a plate 1043 disposed between the
column holding part 1010 and the collection tube holding part 1020. More specifically,
the fluid channel structure 1041 is provided with through holes 1415 penetrated in
the vertical direction at each corner, and a guide pin member 1431 coupled to the
plate 1043 is inserted into each through hole 1415. Through this, the fluid channel
structure 1041 has a shape in which sliding is possible in the vertical direction
on the plate 1043.
[0090] The valve 1042 separates the purified sample and waste introduced from the column
1011 through the first fluid channel 1412 when the fluid channel structure 1041 is
connected to the column 1011 and the collection tube 1021, but the purified sample
is sent to the collection tube 1021 through the second fluid channel 1413, and the
waste is discharged to the waste discharge unit 1030. That is, the valve 1042 is connected
to the first fluid channel 1412 serving as an input fluid channel, the second fluid
channel 1413 serving as an output fluid channel, and the waste discharge part 1030,
and when the fluid introduced through the first fluid channel 1412 is a purified sample,
a fluid channel is formed through the second fluid channel 1413, and when the fluid
introduced through the first fluid channel 1412 is waste, a fluid channel is formed
to the waste discharge part 1030.
[0091] The connection part 1050 allows connection between the column 1011, the separation
part 1040, and the collection tube 1021 for separation, and when separation is completed,
it releases the connection between the column 1011, the separation part 1040, and
the collection tube 1021. In another exemplary embodiment of the present invention,
the connection part 1050 raises the collection tube 1021 to make a connection between
the fluid channel structure 1041, the column 1011, and the collection tube 1021, and
by lowering the collection tube 1021, it allows the connection between the fluid channel
structure 1041, the column 1011, and the collection tube 1021 to be released.
[0092] Referring to FIG. 6, in another exemplary embodiment of the present invention, the
connection part 1050 includes an actuator 1051, a power transmission part 1052, a
ball screw part 1053, and a lifting part 1054. The actuator 1051 may be formed of
a servo motor, and the power transmission part 1052 may transmit a rotational operating
force to a ball screw part 1053 through pulleys and belts. In addition, the ball screw
part 1053 includes a screw rotating by the power transmitted through the power transmission
part 1052, and a ball nut coupled to the screw and linearly moving according to the
rotation of the screw, but the ball nut may be disposed to move along the vertical
direction. Meanwhile, the lifting part 1054 is connected to the ball screw part 53
and is disposed to rise or descend along the vertical direction, and it has a form
capable of gripping the collection tube 21.
[0093] In another exemplary embodiment of the present invention, the lifting part 1054 may
include a gripping part 1451 for gripping the collection tube 1021 and an actuator
1542 that transmits power to the gripping part 1451. In this case, the gripping part
1541 is formed in a shape that may pass through a space between the saw teeth of the
lower plate 1023 in the form of a saw-toothed wheel that supports the lower end of
the collection tube 1021.
[0094] When the separation of one column (1011) is completed such that the separation of
a plurality of samples is performed continuously, the transfer part 1060 transfers
the other column 1011 and the collection tube 1021 disposed corresponding thereto
to a position connectable to the separation unit 1040. The transfer part 1060 may
be configured to rotate the collection tube holding part 1020 and the column holding
part 1010 integrally connected together, and may include an actuator disposed below
the collection tube holding part 1020.
[0095] As described above, in another exemplary embodiment of the present invention, the
centers of the column holding part 1010 and the collection tube holding part 1020
are disposed on the same axis, and the transfer part 1060 rotates the collection tube
holding part 1020 about the axis, and accordingly, the column holding part 1010 may
rotate integrally with the collection tube holding part 1020 about the axis.
[0096] FIGS. 8 and 9 are views showing the operational process of a nuclide separating device
according to another exemplary embodiment of the present invention. Referring to FIGS.
8 and 9, the operational process of the nuclide separating device 1b according to
another exemplary embodiment of the present invention will be described as follows.
[0097] First, a process in which the connection between the column 1011, the separation
part 1040 and the collection tube 1021 is made in the nuclide separating device 1b
will be described with reference to FIG. 8.
[0098] The lifting part 1054 of the connection part 1050 grips the collection tube 1021
while the column 1011 to be separated and the collection tube 1021 corresponding thereto
are disposed on the upper and lower portions, respectively, and as the actuator 1051
of the connection part 1050 rotates in one direction, the lifting part 1054 is raised.
As a result, the open top of the collection tube 1021 is coupled to a collection tube
coupling part 1414 formed at the bottom of a fluid channel structure 1041 of a separation
part 1040, and at the same time, the lower portion of the column 1011 is inserted
into the column coupling part 1411 formed on the upper portion of the fluid channel
structure 1041. In this case, the fluid channel structure 1041 may also be pushed
up as the collection tube 1021 is raised such that the collection tube 1021, the fluid
channel structure 1041, and the column 1011 maybe coupled.
[0099] Simultaneously or sequentially, samples and reagents may be introduced through the
upper portion of the column 1011. The inflow of the sample and the reagent into the
column 1011 is made through an inlet part 1080, and as shown in FIG. 6, the inlet
part 1080 may include an actuator 1081, a power transmission part 1082, a ball screw
part 1083, and an injection part 1084.
[0100] The actuator 1081 may be formed of a servo motor, and the power transmission part
1082 may transmit a rotational operating force to a ball screw part 1083 through pulleys
and belts. In addition, the ball screw part 1083 includes a screw rotating by the
power transmitted through the power transmission part 1082, and a ball nut coupled
to the screw and linearly moving according to the rotation of the screw, but the ball
nut may be disposed to move along the vertical direction. Meanwhile, the injection
part 1084 is connected to the ball screw part 1083 and is disposed to rise or descend
along the vertical direction, and may be connected to a fluid channel (not illustrated)
through which a sample and a reagent are introduced.
[0101] As the actuator 1081 rotates in one direction, the injection part 1084 descends,
and accordingly, the injection part 1084 is coupled to the upper portion of the column
1011. In addition, the coupling between the column 1011 and the fluid channel structure
1041 of the separation part 1040 is more stably performed while the column 1011 is
pressed downward as the injection part 1084 descends.
[0102] Next, a process in which the connection between the column 1011, the separation part
1040, and the collection tube 1021 is released in the nuclide separating device 1b
will be described with reference to FIG. 9.
[0103] When the separation for one column 1011 is completed, the lifting portion 1054 is
lowered as the actuator 1051 of the connection part 1050 rotates in the other direction.
As a result, the coupling of the collection tube 1021 and the collection tube coupling
portion 1414 is released, and at the same time, the lower portion of the column 11
is also detached from the column coupling portion 1411 formed on the upper portion
of the fluid channel structure 1041. In this case, the fluid channel structure 1041
is also lowered by its own weight as the collection tube 1021 descends, and the coupling
of the collection tube 1021, the fluid channel structure 1041, and the column 1011
is released.
[0104] In this case, as shown in FIG. 9, the lifting part 1054 descends to the bottom of
the lower plate 1023 of the collection tube holding part 1020. Accordingly, the collection
tube holding part 1020 and the column holding part 1010 may be rotated by the transfer
part 1060, and as a result, separation for the next column 1011 is prepared.
[0105] Meanwhile, simultaneously or sequentially, as the actuator of the inflow part 1080
rotates in the other direction, the injection part 1084 is also spaced apart from
the upper portion of the column 1011, and the coupling between the injection part
1084 and the column 1011 is also released.
[0106] The nuclide separating device 1b according to another exemplary embodiment of the
present invention may form or release a fluid channel by connecting or disconnecting
different configurations of the upper and lower portions of the column through the
inlet portion 80 disposed at the upper portion of the column and the connection part
50 disposed at the lower portion of the column. More specifically, the connection
part 50 connects or releases the separation part 40 and the lower portion of the column,
and the inlet part 80 is connected to the upper portion of the column in a descending
state such that a reagent or sample is injected into the column, and in a rising state,
it is separated from the top of the column. Accordingly, after transferring the column,
in which extraction is completed, connected to the sample from the fluid channel forming
position, another column in which new extraction proceeds may be disposed at the fluid
channel forming position.
[0107] Although exemplary embodiments of the present invention have been described above,
the spirit of the present invention is not limited to the exemplary embodiments presented
in the present specification, and those skilled in the art who understand the spirit
of the present invention will be able to easily propose other exemplary embodiments
by supplementing, changing, deleting, or adding components within the scope of the
same spirit, but it will be said that these are also within the scope of the spirit
of the present invention.