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EP 3 886 909 A1

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(43) Date of publication: 06.10.2021 Bulletin 2021/40 (21) Application number: 19889759.7 (22) Date of filing: 26.11.2019

(51) International Patent Classification (IPC):  A61K 47/22(2006.01) A61K 47/12(2006.01) A61K 47/20(2006.01) A61K 47/42(2017.01) A61K 39/395(2006.01) A61K 47/18(2017.01) A61K 47/24(2006.01) C07K 16/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/0019; A61K 9/08; A61K 39/39591; A61K 47/02; A61K 47/10; A61K 47/12; A61K 47/14; A61K 47/18; A61K 47/183; A61K 47/20; A61K 47/22; A61K 47/26; A61K 47/40; A61K 47/42; C07K 16/065; C07K 16/22; C07K 16/241; C07K 16/244; C07K 16/2818; C07K 16/2866; C07K 16/32; C07K 16/4291; C07K 2317/21; C07K 2317/24; C07K 2317/76 (86) International application number: PCT/US2019/063374 (87) International publication number: WO 2020/112855 (04.06.2020 Gazette 2020/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.11.2018 US 201862773018 P (71) Applicant: ReForm Biologics, Inc. Woburn, MA 01801 (US)

(72) Inventors: SOANE, David, S. Palm Beach, FL 33480 (US) WUTHRICH, Philip Watertown, MA 02472 (US) MAHONEY, Robert, P. Newbury, MA 01922 (US) MOODY, Mark Concord, MA 01724 (US) GREENE, Daniel, G. Reading, MA 01867 (US) SCHAUER, Neil Milford, MA 01757 (US) NAIK, Subhashchandra Watertown, MA 02472 (US) (74) Representative: Snaith, James Michael  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)