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EP 3 890 603 A1

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(43) Date of publication: 13.10.2021 Bulletin 2021/41 (21) Application number: 19896188.0 (22) Date of filing: 09.12.2019

(51) International Patent Classification (IPC):  A61B 5/0482(2006.01) A61B 5/04(2006.01) A61B 5/055(2006.01) A61B 5/00(2006.01) A61B 5/0484(2006.01) (52) Cooperative Patent Classification (CPC): A61B 5/055; A61B 5/4839; A61B 5/165; A61B 5/377; A61B 5/375 (86) International application number: PCT/IL2019/051345 (87) International publication number: WO 2020/121299 (18.06.2020 Gazette 2020/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.12.2018 US 201862777187 P (71) Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center 6423906 Tel Aviv (IL)

(72) Inventors: HENDLER, Talma 6436101 Tel-Aviv (IL) FRUCHTMAN-STEINBOK, Tom 7647312 Rehovot (IL) COHEN, Avihai 6340306 Tel-Aviv (IL) RAZ, Gal 7312500 Kfar Daniel (IL) (74) Representative: Schäfer, Matthias W.  Patentanwalt Schwanseestrasse 43 81549 München 81549 München (DE)